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Petasis 与 Strecker 氨基酸合成：有机合成中的趋同、发散与机遇。

Petasis vs. Strecker Amino Acid Synthesis: Convergence, Divergence and Opportunities in Organic Synthesis.

机构信息

Department of Chemical and Physical Sciences, Faculty of Natural Sciences, Walter Sisulu University, Nelson Mandela Drive, Mthatha 5117, South Africa.

出版信息

Molecules. 2021 Mar 18;26(6):1707. doi: 10.3390/molecules26061707.

DOI:10.3390/molecules26061707
PMID:33803879
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8003338/
Abstract

α-Amino acids find widespread applications in various areas of life and physical sciences. Their syntheses are carried out by a multitude of protocols, of which Petasis and Strecker reactions have emerged as the most straightforward and most widely used. Both reactions are three-component reactions using the same starting materials, except the nucleophilic species. The differences and similarities between these two important reactions are highlighted in this review.

摘要

α-氨基酸在生命科学和物理科学的各个领域都有广泛的应用。它们的合成是通过多种方案来完成的，其中 Petasis 和 Strecker 反应是最简单、最常用的方法。这两种反应都是三组分反应，使用的起始原料相同，只是亲核试剂不同。本文综述了这两种重要反应之间的差异和相似之处。

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