用于内源性一氧化氮靶向监测的快速且选择性近红外荧光探针的合理设计。
Rational design of a fast and selective near-infrared fluorescent probe for targeted monitoring of endogenous nitric oxide.
作者信息
Tang Junma, Guo Zhiqian, Zhang Yutao, Bai Bing, Zhu Wei-Hong
机构信息
Key Laboratory for Advanced Materials and Institute of Fine Chemicals, Shanghai Key Laboratory of Functional Materials Chemistry, School of Chemistry and Molecular Engineering, East China University of Science & Technology, Shanghai 200237, China.
出版信息
Chem Commun (Camb). 2017 Sep 21;53(76):10520-10523. doi: 10.1039/c7cc05971j.
The real-time monitoring of nitric oxide (NO) at the subcellular level is still a great challenge. To attain this goal, we developed a fast and selective near-infrared (NIR) fluorescent probe for the targeted tracing of endogenous NO. This probe possesses vital features for the real-time detection of intracellular NO including a significant turn-on NIR response, high specificity, and a fast response by a controlled photoinduced electron transfer (PET) process, which is applicable to the real-time monitoring of endogenous NO in mitochondria.
在亚细胞水平对一氧化氮（NO）进行实时监测仍然是一项巨大挑战。为实现这一目标，我们开发了一种用于靶向追踪内源性NO的快速且选择性的近红外（NIR）荧光探针。该探针具有用于实时检测细胞内NO的重要特性，包括显著的近红外开启响应、高特异性以及通过可控的光致电子转移（PET）过程实现的快速响应，适用于线粒体中内源性NO的实时监测。
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