Yamamoto Katsuya, Yakushijin Kimikazu, Kurata Keiji, Mizutani Yu, Inui Yumiko, Uryu Kiyoaki, Kawamoto Shinichiro, Sugimoto Takeshi, Matsuoka Hiroshi, Minami Hironobu
Division of Medical Oncology/Hematology, Department of Medicine, Kobe University Graduate School of Medicine.
Division of Hematological Malignancy, Kita-Harima Medical Center.
Rinsho Ketsueki. 2017;58(8):938-941. doi: 10.11406/rinketsu.58.938.
A 49-year-old female was initially diagnosed with acute myeloid leukemia (AML) M4 with a CD45＋CD13＋CD33＋CD34-HLA-DR＋ immunophenotype. She underwent allogeneic bone marrow transplantation, but the disease recurred. The bone marrow was infiltrated with 87.0% blasts negative for myeloperoxidase (MPO) staining. Immunophenotyping by flow cytometry identified the presence of a CD45-negative blast population. These blasts exhibited a CD13＋CD33＋CD19-CD10-CD34-HLA-DR- immunophenotype. The lack of CD45 expression is often observed in B-cell acute lymphoblastic leukemia, whereas CD45-negative AML is extremely rare; only one older male with AML-M0 has been reported. In the present case, the CD45-negative blasts had an MPO-CD13＋CD33＋ phenotype, which is similar to AML-M0.
一名49岁女性最初被诊断为急性髓系白血病（AML）M4，免疫表型为CD45＋CD13＋CD33＋CD34-HLA-DR＋。她接受了异基因骨髓移植，但疾病复发。骨髓中87.0%的原始细胞髓过氧化物酶（MPO）染色阴性。通过流式细胞术进行免疫表型分析发现存在CD45阴性的原始细胞群。这些原始细胞表现出CD13＋CD33＋CD19-CD10-CD34-HLA-DR-免疫表型。CD45表达缺失在B细胞急性淋巴细胞白血病中经常观察到，而CD45阴性的AML极为罕见；仅报道过1例老年男性AML-M0。在本病例中，CD45阴性的原始细胞具有MPO-CD13＋CD33＋表型，这与AML-M0相似。
