中国南方培养阳性的内源性真菌性眼内炎的临床特征及视力预后
Clinical Features and Visual Acuity Outcomes in Culture-Positive Endogenous Fungal Endophthalmitis in Southern China.
作者信息
Duan Fang, Yang Yao, Yuan Zhaohui, Zheng Yongxin, Cheng Zhixing, Lin Xiaofeng
机构信息
Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Sun Yat-sen University, Guangzhou 510060, China.
出版信息
J Ophthalmol. 2017;2017:3483497. doi: 10.1155/2017/3483497. Epub 2017 Aug 13.
PURPOSE
To report the causative organisms, management strategies, and visual outcomes of culture-proven endogenous fungal endophthalmitis in a case series from southern China.
METHODS
We reviewed the microbiological and medical records of patients with culture-positive endogenous fungal endophthalmitis visiting the Zhongshan Ophthalmic Center, Guangzhou, China, between January 1, 2006, and March 31, 2016.
RESULTS
The inclusion criteria were met in 32 eyes of 29 patients. Molds were a common causative organism in 15 patients (51.7%), while yeasts appeared in 14 patients (48.3%). Initial visual acuity (VA) at the level of finger counting or better was significantly related to a good visual outcome ( = 0.002). Molds as a causative agent were significantly associated with worse visual outcome than yeasts ( = 0.020).
CONCLUSION
Molds were a common cause of culture-proven fungal endophthalmitis. Endogenous fungal endophthalmitis is generally associated with poor VA outcomes, especially if caused by molds and if the patient's initial VA is too low to permit finger counting.
目的
报告中国南方一系列病例中经培养证实的内源性真菌性眼内炎的致病微生物、治疗策略及视力预后情况。
方法
我们回顾了2006年1月1日至2016年3月31日期间在中国广州中山眼科中心就诊的培养阳性的内源性真菌性眼内炎患者的微生物学和医疗记录。
结果
29例患者的32只眼符合纳入标准。霉菌是15例患者（51.7%）常见的致病微生物，而酵母菌出现在14例患者（48.3%）中。初始视力在数指及以上水平与良好的视力预后显著相关（P = 0.002）。作为致病因素，霉菌导致的视力预后比酵母菌显著更差（P = 0.020）。
结论
霉菌是经培养证实的真菌性眼内炎的常见病因。内源性真菌性眼内炎通常与较差的视力预后相关，尤其是由霉菌引起且患者初始视力过低无法数指时。
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