Centre for Eye Research Australia, The Royal Victorian Eye and Ear Hospital, University of Melbourne, East Melbourne, VIC, Australia.
Eye (Lond). 2011 Jan;25(1):66-72. doi: 10.1038/eye.2010.145. Epub 2010 Oct 22.
Endogenous endophthalmitis (EE) is a sight-threatening emergency and the aetiology is often multifactorial. Delayed diagnosis may exacerbate the poor visual prognosis. We describe the management and visual outcomes of EE presenting to a tertiary referral centre.
A prospective consecutive case series of 64 patients presenting with presumed EE from 1997 to 2007 to the Royal Victorian Eye and Ear Hospital were included. All data were collected in a standardized manner. Outcome measures included: visual acuity, microbial profiles, and vitrectomy rate.
In total, 64 cases of EE were identified over the study period with a mean age of 57.5 years, and 53.5% were male. Presenting acuities ranged from Snellen 6/6 to no perception of light (NPL). Identifiable risk factors were present in 78.1%, with the majority related to intravenous drug abuse. A 64.1% culture positivity rate was recorded. A vitrectomy rate of 57, 56, and 21% was recorded in documented bacterial, fungal, and no growth cases, respectively. Final Snellen acuities ranged from 6/6 to NPL. A total of 5 out of 64 eyes were enucleated, of which 3 identified Klebsiella species. Better visual outcome was documented in fungal cases.
EE is a serious ocular condition and has a varied aetiology. Visual outcomes are often poor, irrespective of the method of management. Fungal aetiology often confers a better prognosis, and vitrectomy is advocated for bacterial proven cases.
内源性眼内炎（EE）是一种威胁视力的急症，其病因通常是多因素的。延迟诊断可能会使视力预后恶化。我们描述了在一家三级转诊中心就诊的 EE 的治疗和视力结果。
本研究纳入了 1997 年至 2007 年期间因疑似 EE 就诊于皇家维多利亚眼耳医院的 64 例患者，这些患者均为连续前瞻性病例系列研究。所有数据均以标准化方式收集。观察指标包括：视力、微生物谱和玻璃体切除术率。
在研究期间共发现 64 例 EE 病例，平均年龄为 57.5 岁，53.5%为男性。患者的初始视力范围从 Snellen 6/6 到无光感（NPL）。有明确的危险因素占 78.1%，其中大部分与静脉内药物滥用有关。记录到 64.1%的培养阳性率。在有记录的细菌、真菌和无生长病例中，玻璃体切除术的比例分别为 57%、56%和 21%。最终的 Snellen 视力范围从 6/6 到 NPL。共有 64 只眼中的 5 只被眼球摘除，其中 3 只确定为克雷伯氏菌属。真菌病因的视力预后更好。
EE 是一种严重的眼部疾病，病因多种多样。无论治疗方法如何，视力预后往往都很差。真菌病因通常预后较好，并且提倡对细菌阳性病例进行玻璃体切除术。
