Zabaleta Jon, Aguinagalde Borja, Lopez Iker, Fernandez-Monge Arantza, Izquierdo Jose M, Emparanza Jose I
Thoracic surgery service, Hospital Universitario, Donostia, Gipuzkoa 20014, Spain.
Cancer Biol Med. 2017 Aug;14(3):281-286. doi: 10.20892/j.issn.2095-3941.2017.0073.
: To assess the impact of past liver metastases on the survival duration of patients who are undergoing surgery for lung metastases.
: We conducted a review of literature published from 2007 to 2014. The studies were identified by searching PubMed, MEDLINE, and Embase and were supplemented by a manual search of the references listed by the retrieved studies. The following search terms were used: lung metastasectomy, pulmonary metastasectomy, lung metastases, and lung metastasis. We selected retrospective and prospective studies published from 2007 to 2014 on patients with lung metastases from colorectal cancer and were undergoing surgery with curative intent. We excluded reviews, studies that focused on surgical techniques, patients who were treated non-surgically, analyses of specific subgroups of patients, and those that did not report follow-up of the patients undergoing surgery.
: We identified 28 papers that assessed survival after lung metastases, 21 of which were mostly retrospective studies that identified previous liver metastases to explore their impact on patient survival. In more than half of the papers analyzed (63.2%), patients with a history of resected liver metastases had a lower survival rate than those who did not have such a history, and the difference was statistically significant in eight of these studies. However, data were presented differently, and authors reported mean survival time, survival rates, or hazard ratios.
: A history of liver metastases seems to be a negative prognostic factor, but the individual data need to undergo a meta-analysis.
评估既往肝转移对接受肺转移瘤手术患者生存时间的影响。
我们对2007年至2014年发表的文献进行了综述。通过检索PubMed、MEDLINE和Embase来识别研究，并通过人工检索所检索研究列出的参考文献进行补充。使用了以下检索词：肺转移瘤切除术、肺转移瘤切除术、肺转移、肺转移瘤。我们选择了2007年至2014年发表的关于结直肠癌肺转移患者且接受根治性手术的回顾性和前瞻性研究。我们排除了综述、专注于手术技术的研究、接受非手术治疗的患者、患者特定亚组的分析以及未报告手术患者随访情况的研究。
我们识别出28篇评估肺转移后生存情况的论文，其中21篇大多为回顾性研究，这些研究识别出既往肝转移以探讨其对患者生存的影响。在超过一半（63.2%）的分析论文中，有肝转移切除史的患者生存率低于无此病史的患者，其中八项研究中差异具有统计学意义。然而，数据呈现方式不同，作者报告了平均生存时间、生存率或风险比。
肝转移病史似乎是一个负面预后因素，但个体数据需要进行荟萃分析。
