大鼠基底核神经毒性损伤的皮质效应：外在胆碱能输入的持续丧失以及对含生长抑素、胆碱酯酶阳性和胆碱能皮质神经元数量无跨突触效应。
Cortical effects of neurotoxic damage to the nucleus basalis in rats: persistent loss of extrinsic cholinergic input and lack of transsynaptic effect upon the number of somatostatin-containing, cholinesterase-positive, and cholinergic cortical neurons.
作者信息
Mufson E J, Kehr A D, Wainer B H, Mesulam M M
机构信息
Charles A. Dana Research Institute of Beth Israel Hospital, Boston, MA 02215.
出版信息
Brain Res. 1987 Aug 11;417(2):385-8. doi: 10.1016/0006-8993(87)90470-7.
PMID:2888515
Abstract
Ibotenic acid injections into the nucleus basalis (Ch4) resulted in a near-total loss of cortical cholinesterase fibers. This loss of cholinergic input is irreversible for at least 6 months. The degeneration of cholinergic input has no transsynaptic effect upon the number of cortical somatostatinergic, cholinergic and cholinesterase-positive (cholinoceptive) neurons.
摘要
向基底核（Ch4）注射鹅膏蕈氨酸导致皮质胆碱酯酶纤维几乎完全丧失。这种胆碱能输入的丧失至少6个月内是不可逆的。胆碱能输入的退化对皮质生长抑素能、胆碱能和胆碱酯酶阳性（胆碱感受性）神经元的数量没有跨突触作用。
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