Zeng Chang, Fang Cheng, Weng Hong, Xu Xiaoqing, Wu Tianyang, Li Wenhua
Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University Center for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China.
Medicine (Baltimore). 2017 Sep;96(36):e7855. doi: 10.1097/MD.0000000000007855.
B-cell lymphocyte kinase (BLK) is an inhibitor of B cells that has an important influence on several autoimmune diseases, but there is a lack of comprehensive analysis of its association with autoimmune diseases. Hence, it is meaningful to conduct a comprehensive analysis.
A systematic literature search was performed on the PubMed, ScienceDirect, and Web of Science databases up to June 30, 2016. The data were extracted and quality-assessed before conducting the meta-analysis. The odds ratios (ORs) and 95% confidence intervals (95% CIs) were assessed with the STATA version 12.0 software. Subgroup and sensitivity analysis were conducted to explore potential sources of heterogeneity.
Altogether, 33 studies with 68,874 cases and 90,684 controls, 24 studies with 31,095 cases and 39,077 controls for rs13277113, 21 studies with 26,388 cases and 40,635 controls for rs2736340, and 4 studies with 11,391 cases and 10,972 controls for rs4840568 were included in this meta-analysis. The results revealed that the BLK rs13277113 and rs2736340 polymorphisms increased the risk of autoimmune diseases in the total analysis (A vs G: OR = 1.33, 95% CI = 1.27-1.39, P < .01; T vs C: OR = 1.34, 95% CI = 1.27-1.41, P < .01), and rs4840568 was positively associated with systemic lupus erythematosus (SLE) (A vs G: OR = 1.32, 95% CI = 1.22-1.43, P = .01).
This meta-analysis shows that the BLK (rs13277113, rs2736340, rs4840568) polymorphisms may be a risk factor for developing autoimmune diseases, especially for Asian populations and SLE.
B 细胞淋巴细胞激酶（BLK）是 B 细胞的一种抑制剂，对多种自身免疫性疾病有重要影响，但缺乏对其与自身免疫性疾病关联的综合分析。因此，进行综合分析具有重要意义。
截至 2016 年 6 月 30 日，在 PubMed、ScienceDirect 和 Web of Science 数据库中进行了系统的文献检索。在进行荟萃分析之前，对数据进行提取和质量评估。使用 STATA 12.0 软件评估比值比（OR）和 95%置信区间（95%CI）。进行亚组分析和敏感性分析以探索异质性的潜在来源。
本荟萃分析共纳入 33 项研究，涉及 68874 例病例和 90684 例对照；rs13277113 相关的研究 24 项，涉及 31095 例病例和 39077 例对照；rs2736340 相关的研究 21 项，涉及 26388 例病例和 40635 例对照；rs4840568 相关的研究 4 项，涉及 11391 例病例和 10972 例对照。结果显示，在总体分析中，BLK 的 rs13277113 和 rs2736340 多态性增加了自身免疫性疾病的风险（A 与 G 比较：OR = 1.33，95%CI = 1.27 - 1.39，P <.01；T 与 C 比较：OR = 1.34，95%CI = 1.27 - 1.41，P <.01），且 rs4840568 与系统性红斑狼疮（SLE）呈正相关（A 与 G 比较：OR = 1.32，95%CI = 1.22 - 1.43，P =.01）。
本荟萃分析表明，BLK（rs13277113、rs2736340、rs4840568）多态性可能是自身免疫性疾病发生的危险因素，尤其是对亚洲人群和 SLE。
