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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Tohse N, Hattori Y, Nakaya H, Kanno M

Department of Pharmacology, Hokkaido University School of Medicine, Sapporo, Japan.

Gen Pharmacol. 1987;18(5):539-46. doi: 10.1016/0306-3623(87)90077-2.

Electrophysiological and inotropic responses to stimulation of alpha-adrenoceptors were examined in isolated rat papillary muscles. 2. Stimulation of alpha-adrenoceptors caused two major electrophysiological changes, i.e. prolongation of action potential duration (APD) and hyperpolarization of resting membrane potential. 3. The time course of the inotropic responses to alpha-adrenoceptor stimulation was composed of an initial, short-lasting and small positive phase followed by a negative phase and then a second increasing phase. 4. Nifedipine abolished the alpha-adrenoceptor-mediated positive inotropic effect whereas unaffecting the negative inotropic effect, the APD prolongation and the hyperpolarization. 5. In quiescent muscles alpha-adrenoceptor stimulation also produced hyperpolarization, which was blocked by Ba2+.

在离体大鼠乳头肌中检测了对α-肾上腺素能受体刺激的电生理和变力反应。2. 刺激α-肾上腺素能受体引起两种主要的电生理变化，即动作电位时程（APD）延长和静息膜电位超极化。3. 对α-肾上腺素能受体刺激的变力反应的时间进程由一个初始的、短暂的小正性期，随后是负性期，然后是第二个增强期组成。4. 硝苯地平消除了α-肾上腺素能受体介导的正性变力作用，而不影响负性变力作用、APD延长和超极化。5. 在静止肌肉中，α-肾上腺素能受体刺激也产生超极化，这被Ba2+阻断。

Tohse N, Hattori Y, Nakaya H, Kanno M

Department of Pharmacology, Hokkaido University School of Medicine, Sapporo, Japan.

Gen Pharmacol. 1987;18(5):539-46. doi: 10.1016/0306-3623(87)90077-2.

Electrophysiological and inotropic responses to stimulation of alpha-adrenoceptors were examined in isolated rat papillary muscles. 2. Stimulation of alpha-adrenoceptors caused two major electrophysiological changes, i.e. prolongation of action potential duration (APD) and hyperpolarization of resting membrane potential. 3. The time course of the inotropic responses to alpha-adrenoceptor stimulation was composed of an initial, short-lasting and small positive phase followed by a negative phase and then a second increasing phase. 4. Nifedipine abolished the alpha-adrenoceptor-mediated positive inotropic effect whereas unaffecting the negative inotropic effect, the APD prolongation and the hyperpolarization. 5. In quiescent muscles alpha-adrenoceptor stimulation also produced hyperpolarization, which was blocked by Ba2+.

在离体大鼠乳头肌中检测了对α-肾上腺素能受体刺激的电生理和变力反应。2. 刺激α-肾上腺素能受体引起两种主要的电生理变化，即动作电位时程（APD）延长和静息膜电位超极化。3. 对α-肾上腺素能受体刺激的变力反应的时间进程由一个初始的、短暂的小正性期，随后是负性期，然后是第二个增强期组成。4. 硝苯地平消除了α-肾上腺素能受体介导的正性变力作用，而不影响负性变力作用、APD延长和超极化。5. 在静止肌肉中，α-肾上腺素能受体刺激也产生超极化，这被Ba2+阻断。