当不符合模式时：一种特异性改变的百日咳样毒素。
When doesn't fit the mold: A pertussis-like toxin with altered specificity.
作者信息
Chen Chen, Barbieri Joseph T
机构信息
From the Department of Microbiology and Immunology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226.
From the Department of Microbiology and Immunology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226
出版信息
J Biol Chem. 2017 Sep 8;292(36):15159-15160. doi: 10.1074/jbc.H117.796094.
Abstract
Bacterial toxins introduce protein modifications such as ADP-ribosylation to manipulate host cell signaling and physiology. Several general mechanisms for toxin function have been established, but the extent to which previously uncharacterized toxins utilize these mechanisms is unknown. A study of an pertussis-like toxin demonstrates that this protein acts on a known toxin substrate but displays distinct and dual chemoselectivity, suggesting this pertussis-like toxin may serve as a unique tool to study G-protein signaling in eukaryotic cells.
摘要
细菌毒素会引发蛋白质修饰，如ADP核糖基化，以操纵宿主细胞信号传导和生理功能。毒素作用的几种一般机制已经确立，但此前未被鉴定的毒素利用这些机制的程度尚不清楚。一项关于类百日咳毒素的研究表明，这种蛋白质作用于一种已知的毒素底物，但表现出独特的双重化学选择性，这表明类百日咳毒素可能是研究真核细胞中G蛋白信号传导的独特工具。
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