The influence of viscosity on the migration of chloramphenicol and 4-hydroxybenzoic acid through glycerogelatin gels.
作者信息
Armstrong N A, Gebre-Mariam T, James K C, Kearney P
机构信息
Welsh School of Pharmacy, University of Wales Institute of Science and Technology, Cardiff, UK.
出版信息
J Pharm Pharmacol. 1987 Aug;39(8):583-6. doi: 10.1111/j.2042-7158.1987.tb03433.x.
Abstract
Migration of chloramphenicol and 4-hydroxybenzoic acid from solutions in 1-octanol into Glycerol Suppository Base, BP and soft gelatin capsule shells is reported. Rates of migration through the gels, quantified in terms of diffusion coefficients, are given. An electron spin resonance probing technique was used to determine the microscopic viscosity. The latter, rather than the bulk viscosity, was shown to be the major rheological influence on the rate of diffusion.
摘要
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