Armstrong N A, Gebre-Mariam T, James K C, Kearney P
Welsh School of Pharmacy, University of Wales Institute of Science and Technology, Cardiff, UK.
J Pharm Pharmacol. 1987 Aug;39(8):583-6. doi: 10.1111/j.2042-7158.1987.tb03433.x.
Migration of chloramphenicol and 4-hydroxybenzoic acid from solutions in 1-octanol into Glycerol Suppository Base, BP and soft gelatin capsule shells is reported. Rates of migration through the gels, quantified in terms of diffusion coefficients, are given. An electron spin resonance probing technique was used to determine the microscopic viscosity. The latter, rather than the bulk viscosity, was shown to be the major rheological influence on the rate of diffusion.
