自我毁灭的狂犬病病毒在 DNA 上留下痕迹。
A Self-Killing Rabies Virus That Leaves a Trace on the DNA.
机构信息
Center for Brain Science, Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA, USA.
Center for Brain Science, Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA, USA.
出版信息
Trends Neurosci. 2017 Oct;40(10):589-591. doi: 10.1016/j.tins.2017.08.005. Epub 2017 Sep 7.
PMID:28890212
Abstract
Although modified rabies viruses have emerged as a powerful tool for tracing the inputs to genetically defined populations of neurons, the toxicity of the virus has limited its utility. A recent study employed a self-inactivating rabies (SiR) virus that enables recording or manipulation of targeted neurons for months.
摘要
虽然经过修饰的狂犬病病毒已成为追踪遗传定义的神经元群体传入信息的有力工具，但该病毒的毒性限制了其应用。最近的一项研究采用了一种自我失活的狂犬病（SiR）病毒，该病毒能够使目标神经元的记录或操作持续数月。
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