长链非编码RNA H19在肌肉骨骼系统中的作用：旧有领域中的新角色。
The role of long non-coding RNA H19 in musculoskeletal system: A new player in an old game.
作者信息
Liu Yang, Li Gang, Zhang Jin-Fang
机构信息
Department of Orthopaedics and Traumatology, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China.
Department of Orthopaedics and Traumatology, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China; Stem Cells and Regenerative Medicine Laboratory, Lui Che Woo Institute of Innovative Medicine, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China; Key Laboratory for Regenerative Medicine, Ministry of Education, School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China; The CUHK-ACC Space Medicine Centre on Health Maintenance of Musculoskeletal System, The Chinese University of Hong Kong Shenzhen Research Institute, Shenzhen, China.
出版信息
Exp Cell Res. 2017 Nov 15;360(2):61-65. doi: 10.1016/j.yexcr.2017.09.007. Epub 2017 Sep 7.
The long non-coding RNAs (lncRNAs) have gained much attention due to its essential roles in molecular regulation. As one of the classic lncRNAs, H19 is strongly expressed during embryogenesis and plays a crucial biological function during development. Mesenchymal stem cells (MSCs) are an ideal cell source for tissue engineering in musculoskeletal system as they own the multi-differentiation ability towards osteogenesis, adipogenesis, tenogenesis or chondrogenesis. In recent years, many studies have been found in the field of H19 mediated cellular differentiation of MSCs. Here, we summarized the current understanding of H19 during multi-differentiation of MSCs and its application in tissue regeneration of musculoskeletal system. Particularly, its molecular regulation and biological function during the multi-differentiation were also discussed.
长链非编码RNA（lncRNAs）因其在分子调控中的重要作用而备受关注。作为经典lncRNAs之一，H19在胚胎发育过程中高表达，并在发育过程中发挥关键生物学功能。间充质干细胞（MSCs）是肌肉骨骼系统组织工程的理想细胞来源，因为它们具有向成骨、成脂、成腱或成软骨分化的多分化能力。近年来，在H19介导的MSCs细胞分化领域有许多研究被发现。在此，我们总结了目前对H19在MSCs多分化过程中的认识及其在肌肉骨骼系统组织再生中的应用。特别地，还讨论了其在多分化过程中的分子调控和生物学功能。
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