Türkmen Osman, Karalok Alper, Başaran Derman, Kimyon Günsu, Kul Gizem, Tulunay Gökhan, Üreyen Işın, Turan Taner
Department of Gynecologic Oncology, Etlik Zübeyde Hanım Women's Health Training and Research Hospital, Ankara, Turkey.
J Turk Ger Gynecol Assoc. 2017 Sep 1;18(3):110-115. doi: 10.4274/jtgga.2017.0033.
This study aimed to define factors that affected survival in the International Federation of Gynecology and Obstetrics (FIGO) 1988 stage IIIA endometrial cancer (EC).
The study included patients with EC who underwent surgery between 1992 and 2013. Patients with adnexal metastases, uterine serosal involvement or positive peritoneal cytology (stage IIIA disease according to the former 1988 FIGO staging system) were selected for further analysis. Clinical and pathologic factors associated with progression-free survival (PFS) were evaluated using univariate and multivariate statistical tests.
Seventy-seven patients with stage IIIA disease according to the 1988 FIGO staging system were included. The median follow-up was 37 months (range, 1-175 months) and recurrence was detected in 19 patients. Univariate analysis revealed that the presence of uterine serosal invasion and advanced histologic grade (grade 1-2 vs. grade 3) were associated with diminished PFS (p=0.001, p=0.047). The presence of adnexal involvement and positive peritoneal cytology had no statistically significant influence on PFS (p=0.643 and p=0.795, respectively).
In patients with stage IIIA EC according to the FIGO 1988 staging system, only uterine serosal involvement was related with adverse oncologic outcomes, not adnexal involvement or presence of positive cytology.
本研究旨在确定影响国际妇产科联盟（FIGO）1988年分期为IIIA期子宫内膜癌（EC）患者生存的因素。
本研究纳入了1992年至2013年间接受手术的EC患者。选择有附件转移、子宫浆膜受累或腹水细胞学阳性（根据1988年FIGO分期系统为IIIA期疾病）的患者进行进一步分析。使用单因素和多因素统计检验评估与无进展生存期（PFS）相关的临床和病理因素。
纳入了77例根据1988年FIGO分期系统为IIIA期疾病的患者。中位随访时间为37个月（范围1 - 175个月），19例患者检测到复发。单因素分析显示子宫浆膜侵犯和高级别组织学分级（1 - 2级与3级）与PFS降低相关（p = 0.001，p = 0.047）。附件受累和腹水细胞学阳性对PFS无统计学显著影响（分别为p = 0.643和p = 0.795）。
对于根据FIGO 1988分期系统为IIIA期EC的患者，只有子宫浆膜受累与不良肿瘤学结局相关，而附件受累或腹水细胞学阳性则不然。
