Rosa-Grilo Miguel, Qamar Mubasher A, Taddei Raquel N, Pagonabarraga Javier, Kulisevsky Jaime, Sauerbier Anna, Chaudhuri K Ray
National Parkinson Foundation (NPF) International Center of Excellence at King's College Hospital, London, UK.
Department of Basic and Clinical Neuroscience, The Maurice Wohl Clinical Neuroscience Institute, King's College London and National Institute for Health Research (NIHR) Mental Health Biomedical Research Centre, Institute of Psychology, Psychiatry and Neurosciences, King's College London, London, UK.
NPJ Parkinsons Dis. 2017 Sep 5;3:28. doi: 10.1038/s41531-017-0030-4. eCollection 2017.
A wide range of sleep dysfunction complicates Parkinson's disease during its course from prodromal to palliative stage. It is now increasingly acknowledged that sleep disturbances are thus integral to the disease and pose a significant burden impacting on quality of life of patients. Sleep fragmentation, restless legs syndrome, nocturia, and nocturnal pain are regarded as one of the main components of night-time sleep dysfunction with possible secondary impact on cognition and well-being. The role of dopaminergic therapies, particularly using a continuous drug delivery strategy in managing some of these sleep issues, have been reported but the overall concept remains unclear. This review provides an overview of several aspects of night-time sleep dysfunction in Parkinson's disease and describes all available published open-label and blinded studies that investigated the use of rotigotine transdermal patch targeting sleep. Blinded studies have suggested beneficial effects of rotigotine transdermal patch on maintenance insomnia and restless legs syndrome in Parkinson's disease patients. Open-label studies support these observations and also suggest beneficial effects on nocturia and nocturnal pain.
在帕金森病从前驱期到姑息期的病程中，多种睡眠功能障碍使其病情复杂化。现在人们越来越认识到，睡眠障碍是该疾病不可或缺的一部分，并且对患者的生活质量造成了重大负担。睡眠片段化、不宁腿综合征、夜尿症和夜间疼痛被视为夜间睡眠功能障碍的主要组成部分之一，可能对认知和幸福感产生继发性影响。多巴胺能疗法的作用，特别是采用持续给药策略来处理其中一些睡眠问题，已有报道，但总体概念仍不明确。本综述概述了帕金森病夜间睡眠功能障碍的几个方面，并描述了所有已发表的、研究使用罗替戈汀透皮贴剂治疗睡眠的开放标签和盲法研究。盲法研究表明，罗替戈汀透皮贴剂对帕金森病患者的维持性失眠和不宁腿综合征有有益效果。开放标签研究支持这些观察结果，并且还表明对夜尿症和夜间疼痛有有益效果。
