中西医结合对儿童夜间遗尿症的影响及治疗成功指标：随机对照试验。

Effect of traditional Chinese and Western medicine on nocturnal enuresis in children and indicators of treatment success: Randomized controlled trial.

作者信息

Ma Yanli, Liu Xiaomei, Shen Ying

机构信息

Department of Nephrology, Beijing Children's Hospital, National Center for Children's Health, Beijing Key Laboratory of Chronic Kidney Disease and Blood Purification of Children, Capital Medical University, Xicheng District, Beijing, China.

出版信息

Pediatr Int. 2017 Nov;59(11):1183-1188. doi: 10.1111/ped.13417.

DOI:10.1111/ped.13417

PMID:28891253

Abstract

BACKGROUND

Nocturnal enuresis (NE) is a common pediatric developmental disorder. Desmopressin is frequently used for NE and is an evidence-based therapy. Suoquan capsule is a Chinese medicine commonly used for treating NE in children but is poorly understood by most scholars.

METHODS

A total of 369 children with NE were randomized to receive either suoquan, desmopressin plus suoquan, desmopressin, or behavioral intervention for 2 months, and the response rates evaluated. Subsequently, the viable demographic factors that could lead to success were investigated on logistic regression analysis. Moreover, after 3 months of follow up, the relapse rate was investigated.

RESULTS

The complete response (CR) rate in the desmopressin plus suoquan group (37.5%) was higher than that in the behavioral intervention group (6.3%, P < 0.007). The desmopressin group had a lower CR rate (22.5%) and a higher non-response rate (25.0%) than the desmopressin plus suoquan group (non-response rate, 21.9%; P > 0.007). The relapse rate in the desmopressin group was significantly higher than that in the desmopressin plus suoquan group (72.2% vs. 30.6%, P < 0.007). On Multivariate analysis, treatment group, NE frequency, and age were independent predictors of CR at 2 months (P < 0.05).

CONCLUSIONS

Combined traditional Chinese and Western treatment in children with NE is effective and has a low relapse rate. NE frequency, treatment method, and age are important predictive factors for CR after treatment.

摘要

背景

夜间遗尿症（NE）是一种常见的儿科发育障碍。去氨加压素常用于治疗NE，是一种循证疗法。缩泉胶囊是一种常用于治疗儿童NE的中药，但大多数学者对其了解甚少。

方法

总共369例NE患儿被随机分为接受缩泉胶囊、去氨加压素加缩泉胶囊、去氨加压素或行为干预治疗2个月，并评估有效率。随后，通过逻辑回归分析研究可能导致治疗成功的可行人口统计学因素。此外，在随访3个月后，调查复发率。

结果

去氨加压素加缩泉胶囊组的完全缓解（CR）率（37.5%）高于行为干预组（6.3%，P < 0.007）。去氨加压素组的CR率（22.5%）低于去氨加压素加缩泉胶囊组（无反应率，21.9%；P > 0.007），且无反应率（25.0%）高于去氨加压素加缩泉胶囊组。去氨加压素组的复发率显著高于去氨加压素加缩泉胶囊组（72.2%对30.6%，P < 0.007）。多因素分析显示，治疗组、NE发作频率和年龄是2个月时CR的独立预测因素（P < 0.05）。