稳定型心绞痛患者单核细胞与淋巴细胞比值与冠状动脉斑块易损性的关系
Relationship between monocyte-to-lymphocyte ratio and coronary plaque vulnerability in patients with stable angina.
作者信息
Fan Zeyuan, Ji Hanhua, Li Yang, Jian Xinwen, Li Li, Liu Tao
机构信息
Department of Cardiovascular Diseases, Civil Aviation General Hospital, Civil Aviation Clinical Medical College of Peking University, Beijing, China.
出版信息
Biomark Med. 2017 Nov;11(11):979-990. doi: 10.2217/bmm-2017-0235. Epub 2017 Sep 11.
AIM
To investigate the relationship between monocyte-to-lymphocyte ratio (MLR) and plaque vulnerability assessed by virtual histology intravascular ultrasound in patients with stable angina.
METHODS
133 patients with stable angina were enrolled.
RESULTS
MLR was found to be an independent risk factor of thin cap fibrous atheroma (OR: 2.61; p = 0.025). MLR could differentiate thin cap fibrous atheroma with a sensitivity of 73.7% and a specificity of 61.8%. MLR level was positively correlated with the percentage of necrotic core (NC) area at the sites of minimum lumen area and the largest NC area, and positively related to the percentage of NC volume.
CONCLUSION
Circulating MLR level has potential in identifying the vulnerable plaques in the setting of stable angina.
目的
探讨单核细胞与淋巴细胞比值（MLR）与稳定型心绞痛患者经虚拟组织学血管内超声评估的斑块易损性之间的关系。
方法
纳入133例稳定型心绞痛患者。
结果
发现MLR是薄帽纤维粥样斑块的独立危险因素（比值比：2.61；p = 0.025）。MLR能够鉴别薄帽纤维粥样斑块，敏感性为73.7%，特异性为61.8%。MLR水平与最小管腔面积处坏死核心（NC）面积百分比、最大NC面积以及NC体积百分比呈正相关。
结论
循环MLR水平在识别稳定型心绞痛患者的易损斑块方面具有潜力。
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