Medical Faculty, Lazarski University in Warsaw, 02-662 Warsaw, Poland.
Department of Internal Medicine and Geriatric Cardiology, Centre of Postgraduate Medical Education, 01-813 Warsaw, Poland.
Int J Mol Sci. 2022 Aug 23;23(17):9553. doi: 10.3390/ijms23179553.
Atherosclerosis, the underlying cause of coronary artery disease (CAD), has a significant inflammatory component. White blood cell count is an affordable and accessible way to assess the systemic immune response, as it comprises many subgroups with distinct and complex functions. Considering their multidirectional effect on atherosclerosis, new biomarkers integrating various leukocyte subgroups, the Systemic Inflammatory Index (SII) and the Systemic Inflammatory Response Index (SIRI), were recently devised to describe the balance between inflammation and immune reaction. This research aimed to evaluate the relationship of the intensity of inflammation measured by these biomarkers with the severity of CAD assessed with coronary angiography and with the diagnosis of acute coronary syndrome (ACS) or stable CAD in 699 patients. SIRI, but not SII, was associated with the diagnosis, having the highest values for patients with ACS (STEMI), significantly higher than in patients with stable CAD (p < 0.01). The highest SII and SIRI values were observed in patients with three-vessel CAD. SII and SIRI require further in-depth and well-designed research to evaluate their potential in a clinical setting.
动脉粥样硬化是冠心病（CAD）的根本原因，具有显著的炎症成分。白细胞计数是评估全身免疫反应的一种经济实惠且易于获得的方法，因为它包含许多具有不同且复杂功能的亚群。考虑到它们对动脉粥样硬化的多向影响，最近设计了新的生物标志物，将各种白细胞亚群、系统性炎症指数（SII）和系统性炎症反应指数（SIRI）整合在一起，以描述炎症和免疫反应之间的平衡。本研究旨在评估这些生物标志物所测量的炎症强度与冠状动脉造影评估的 CAD 严重程度以及在 699 例患者中急性冠状动脉综合征（ACS）或稳定型 CAD 的诊断之间的关系。SIRI，但不是 SII，与诊断相关，ACS（ST 段抬高型心肌梗死）患者的 SIRI 值最高，明显高于稳定型 CAD 患者（p < 0.01）。三血管 CAD 患者的 SII 和 SIRI 值最高。SII 和 SIRI 需要进一步深入和精心设计的研究，以评估其在临床环境中的潜力。
