传统光疗与LED光疗对早产黄疸新生儿抗氧化-氧化状态的影响

Effect of Conventional and LED Phototherapy on the Antioxidant-Oxidant Status in Preterm Neonates with Jaundice.

作者信息

Allam Anusha, Ravikiran S R, Baliga B Shantaram, Bhat Kamalakshi, Joseph Nitin

机构信息

Departments of Pediatrics and *Community Medicine, Kasturba Medical College, Mangalore, Manipal University, Karnataka, India. Correspondence to: Dr SR Ravikiran, Associate Professor, Department of Pediatrics, Kasturba Medical College, Attavar KMC Hospital, Mangalore, Karnataka, India.

出版信息

Indian Pediatr. 2017 Aug 15;54(8):644-646. doi: 10.1007/s13312-017-1127-x.

DOI:10.1007/s13312-017-1127-x

PMID:28891476

Abstract

OBJECTIVE

To compare oxidative stress due to conventional and LED phototherapy among jaundiced preterm neonates.

METHODS

Cross-sectional study conducted in NICU on 82 neonates (equal numbers received conventional and LED phototherapy). Total antioxidant capacity (TAC), total oxidant status (TOS) and Oxidative stress index (OSI) were assessed.

RESULTS

Post-phototherapy, mean (SD) OSI increased significantly compared to baseline in both conventional [0.26 (0.24) vs. 0.61 (0.41); P<0.001] and LED groups [0.24 (0.20) vs. 0.32 (0.23); P<0.001]. Across groups, mean (SD) TAC was lower [0.28 (0.16) vs. 0.53 (0.27); P<0.001] mmol Trolox equiv/L; mean (SD) TOS higher [15.6 (10.9) vs. 14.6 (10.2); P=0.711] µmol H2O2/L and mean (SD) OSI higher [0.61 (0.42) vs. 0.33 (0.23); P<0.001] in conventional as compared to LED phototherapy.

CONCLUSION

Both modes increased oxidative stress index; however, conventional phototherapy resulted in higher oxidative stress.

摘要

目的

比较接受传统光疗和LED光疗的黄疸早产儿的氧化应激情况。

方法

在新生儿重症监护病房对82例新生儿进行横断面研究（接受传统光疗和LED光疗的人数相等）。评估总抗氧化能力（TAC）、总氧化状态（TOS）和氧化应激指数（OSI）。

结果

光疗后，传统光疗组[0.26（0.24）对0.61（0.41）；P<0.001]和LED光疗组[0.24（0.20）对0.32（0.23）；P<0.001]的平均（标准差）OSI较基线均显著升高。两组间，传统光疗组的平均（标准差）TAC较低[0.28（0.16）对0.53（0.27）；P<0.001]mmol Trolox当量/L；平均（标准差）TOS较高[15.6（10.9）对14.6（10.2）；P=0.711]μmol H2O2/L，平均（标准差）OSI较高[0.61（0.42）对0.33（0.23）；P<0.001]。