Department of Chemistry, University of Nairobi, Nairobi, P.O. Box 30197-00100, Kenya.
Global Emerging Infections Surveillance (GEIS) Program, United States Army Medical Research Unit-Kenya (USAMRU-K), Kenya Medical Research Institute (KEMRI)-Walter Reed Project, Kisumu and Nairobi, P.O. Box 54-40100, Kisumu, Kenya.
Molecules. 2017 Sep 10;22(9):1514. doi: 10.3390/molecules22091514.
Four new flavones with modified prenyl groups, namely ()-5-hydroxytephrostachin (), purleptone (), ()-5-hydroxyanhydrotephrostachin (), and terpurlepflavone (), along with seven known compounds (-), were isolated from the CH₂Cl₂/MeOH (1:1) extract of the stem of subsp. , a widely used medicinal plant. Their structures were elucidated on the basis of NMR spectroscopic and mass spectrometric evidence. Some of the isolated compounds showed antiplasmodial activity against the chloroquine-sensitive D6 strains of with ()-5-hydroxytephrostachin () being the most active, IC 1.7 ± 0.1 μM, with relatively low cytotoxicity, IC > 21 μM, against four cell-lines.
从药用植物 subsp. 的茎的 CH₂Cl₂/MeOH（1:1）提取物中分离得到了四个具有修饰的prenyl 基团的新类黄酮，即()-5-羟基tephrostachin ()、purleptone ()、()-5-羟基anhydrotephrostachin ()和terpurlepflavone ()，以及七个已知化合物 (-)。基于 NMR 光谱和质谱证据阐明了它们的结构。一些分离得到的化合物对氯喹敏感的 D6 株具有抗疟原虫活性，其中 ()-5-羟基tephrostachin ()活性最强，IC 1.7 ± 0.1 μM，对四种细胞系的细胞毒性相对较低，IC > 21 μM。
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