Morante-Carriel Jaime, Nájera Hugo, Samper-Herrero Antonio, Živković Suzana, Martínez-Esteso María José, Martínez-Márquez Ascensión, Sellés-Marchart Susana, Obrebska Anna, Bru-Martínez Roque
Plant Proteomics and Functional Genomics Group, Department of Biochemistry and Molecular Biology and Soil and Agricultural Chemistry, Faculty of Science, University of Alicante, Carretera San Vicente del Raspeig s/n, 03690 San Vicente del Raspeig, Alicante, Spain.
Plant Biotechnology Group, Faculty of Forestry and Agricultural Sciences, Quevedo State Technical University, Av. Quito km. 1 1/2 vía a Santo Domingo de los Tsáchilas, Quevedo 120501, Ecuador.
Int J Mol Sci. 2024 Dec 4;25(23):13036. doi: 10.3390/ijms252313036.
Much attention has been paid to the potential biological activities of prenylated flavonoids (PFs) in various plant families over the last decade. They have enormous potential for biological activities, such as anti-cancer, anti-diabetic, antimicrobial, anti-inflammatory, anti-Alzheimer's, and neuroprotective activities. Medicinal chemists have recently shown a strong interest in PFs, as they are critical to the development of new medicines. PFs have been rapidly prepared by isolation and semi- or full synthesis, demonstrating their significant utility in medicinal chemistry research. This study encompasses the research progress on PFs in the last decade, including their pharmacological activities in the Fabaceae family. This information demonstrates the bioactive potential of PF compounds and their role in the control and treatment of various human health problems.
在过去十年中，人们对各种植物科中的异戊烯基黄酮（PFs）的潜在生物活性给予了极大关注。它们具有巨大的生物活性潜力，如抗癌、抗糖尿病、抗菌、抗炎、抗阿尔茨海默病和神经保护活性。药物化学家最近对PFs表现出浓厚兴趣，因为它们对新药开发至关重要。通过分离以及半合成或全合成已快速制备出PFs，这表明它们在药物化学研究中具有重要用途。本研究涵盖了过去十年中PFs的研究进展，包括它们在豆科植物中的药理活性。这些信息证明了PF化合物的生物活性潜力及其在控制和治疗各种人类健康问题中的作用。
