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FeCl₃∙6H₂O/TMSBr 催化微波辐射下二氢嘧啶酮和二氢嘧啶硫酮的快速合成。

FeCl₃∙6H₂O/TMSBr-Catalyzed Rapid Synthesis of Dihydropyrimidinones and Dihydropyrimidinethiones under Microwave Irradiation.

机构信息

Antibiotics Research and Re-Evaluation Key Laboratory of Sichuan Province, Sichuan Industrial Institute of Antibiotics, Chengdu University, 168 Hua Guan Road, Chengdu 610052, China.

出版信息

Molecules. 2017 Sep 11;22(9):1503. doi: 10.3390/molecules22091503.

DOI:10.3390/molecules22091503
PMID:28892005
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6151402/
Abstract

An efficient and practical protocol has been developed to synthesize dihydropyrimidinones and dihydropyrimidinethiones through FeCl₃∙6H₂O/TMSBr-catalyzed three-component cyclocondensation under microwave irradiation. This approach features high yields, broad substrate scope, short reaction time, mild reaction conditions, operational simplicity and easy work-up, thus affording a versatile method for the synthesis of dihydropyrimidinones and dihydropyrimidinethiones.

摘要

开发了一种高效实用的合成二氢嘧啶酮和二氢嘧啶硫酮的方法，该方法通过 FeCl₃·6H₂O/TMSBr 催化的微波辐射下的三组分环缩合反应实现。该方法具有产率高、底物范围广、反应时间短、反应条件温和、操作简单、后处理方便等优点，为二氢嘧啶酮和二氢嘧啶硫酮的合成提供了一种通用方法。

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