Natural Science Laboratory, Division of Medicinal and Pharmaceutical Chemistry, Department of Pharmaceutical Technology, P.O. Box 17020, Jadavpur University, Kolkata 700032, WB, India.
Laboratory of Drug Design and Discovery, Department of Pharmaceutical Sciences, Dr. Harisingh Gour University, Sagar 470003, MP, India.
Biomed Pharmacother. 2017 Nov;95:818-827. doi: 10.1016/j.biopha.2017.09.004. Epub 2017 Sep 10.
A number of people worldwide have been suffering from ocular neovascularization that may be treated by a variety of drugs but these may possess adverse effects. Therefore, small antiangiogenic molecules with higher potency and lower toxic effects are intended. However, homoisoflavonoids of natural origin show the potential antiangiogenic effect in ocular neovascularization. These homoisoflavonoids are judged quantitatively in terms of statistical validation through multi-chemometric modeling approaches for the betterment and refinement of their structures required for higher antiangiogenic activity targeted to ocular neovascularization. These approaches may be utilized to design better antiangiogenic homoisoflavonoids.
全世界有许多人患有眼内新生血管化，可通过多种药物治疗，但这些药物可能具有不良反应。因此，旨在开发具有更高效力和更低毒副作用的小的抗血管生成分子。然而，天然来源的异黄酮类化合物在眼内新生血管化中显示出潜在的抗血管生成作用。这些异黄酮类化合物通过多化学计量建模方法进行定量评估，通过统计验证来判断其结构的改善和优化，以提高针对眼内新生血管化的抗血管生成活性。这些方法可用于设计更好的抗血管生成异黄酮类化合物。
