母体主动和被动吸烟对健康不良影响的修饰作用受遗传易感性影响：日本女性中血浆可替宁与婴儿出生体重的剂量依赖性关联——北海道研究。

Modification of adverse health effects of maternal active and passive smoking by genetic susceptibility: Dose-dependent association of plasma cotinine with infant birth size among Japanese women-The Hokkaido Study.

机构信息

Center for Environmental and Health Sciences, Hokkaido University, North-12, West-7, Kita-ku, Sapporo, Hokkaido 060-0812, Japan; Department of Public Health Sciences, Hokkaido University Graduate School of Medicine, North-15, West-7, Kita-ku, Sapporo, Hokkaido 060-8638, Japan.

Center for Environmental and Health Sciences, Hokkaido University, North-12, West-7, Kita-ku, Sapporo, Hokkaido 060-0812, Japan; Health Center, Chuo University, 42-8, Ichigaya-Hommura-cho, Shinjuku-ku, Tokyo 162-8473, Japan.

出版信息

Reprod Toxicol. 2017 Dec;74:94-103. doi: 10.1016/j.reprotox.2017.09.002. Epub 2017 Sep 8.

DOI:10.1016/j.reprotox.2017.09.002

PMID:28893607

Abstract

OBJECTIVES

We aimed to assess the individual dose-response effects of eight maternal polymorphisms encoding polycyclic aromatic hydrocarbon-metabolizing and DNA-repair genes on prenatal cotinine levels according to infant birth size.

METHODS

In total, 3263 Japanese pregnant women were assigned to five groups based on plasma cotinine levels during the 8th month of pregnancy, as measured using ELISA (cut-offs: 0.21, 0.55, 11.48, and 101.67ng/mL). Analyses were performed using multiple linear regression.

RESULTS

Birth weight reduction showed a dose-dependent relationship with prenatal cotinine levels (P for trend<0.001). When considering the specific aromatic hydrocarbon receptor (AHR) (G>A, Arg554Lys; db SNP ID: rs2066853) and X-ray cross-complementing gene 1 (XRCC1) (C>T, Arg194Trp, rs1799782) genotypes, a larger birth weight reduction was noted among infants born to mothers with the highest cotinine level.

CONCLUSION

Infants born to women with specific AHR and XRCC1 genotypes may have higher genetic risks for birth weight reduction.

摘要

目的

根据婴儿出生体重大小，评估编码多环芳烃代谢和 DNA 修复基因的 8 种母体多态性对产前可替宁水平的个体剂量反应效应。

方法

共有 3263 名日本孕妇根据酶联免疫吸附测定法（ELISA）（检测限：0.21、0.55、11.48 和 101.67ng/mL）测量的第 8 个月妊娠期间血浆可替宁水平，被分为五组。采用多元线性回归进行分析。

结果

体重减轻与产前可替宁水平呈剂量依赖性关系（趋势 P<0.001）。考虑到特定芳香烃受体（AHR）（G>A，Arg554Lys；db SNP ID：rs2066853）和 X 射线修复交叉互补基因 1（XRCC1）（C>T，Arg194Trp，rs1799782）基因型时，可替宁水平最高的母亲所生婴儿的体重减轻幅度更大。