Miyata T, Kai H, Furusawa K, Nakamura H, Saito M, Okano Y, Takahama K
Department of Pharmacological Sciences, Faculty of Pharmaceutical Sciences, Kumamoto University, Japan.
Arch Int Pharmacodyn Ther. 1987 Jul;288(1):147-60.
Action of mabuterol, a novel bronchodilator, on the respiratory secretion system was investigated, and the following effects were confirmed: 1) increase of output volume, amounts of protein and pulmonary surfactant in respiratory fluid; 2) decrease of sputum viscosity; 3) fragmentation of the sputum structure and 4) promotion of the mucociliary transport of particles. The results in the present study may, at least partly, substantiate clinical efficacy such as improvement of pulmonary function, favourable effects on expectoration and amelioration of symptoms observed in patients with chronic obstructive pulmonary disease.
研究了新型支气管扩张剂马布特罗对呼吸分泌系统的作用，并证实了以下效果：1）呼吸液中输出量、蛋白量和肺表面活性物质增加；2）痰液粘度降低；3）痰液结构破碎；4）促进颗粒的黏液纤毛运输。本研究结果可能至少部分证实了诸如改善肺功能、对咳痰的有利影响以及慢性阻塞性肺疾病患者症状改善等临床疗效。
