迟发性运动障碍与硫利达嗪的稳态血清水平
Tardive dyskinesia and steady-state serum levels of thiothixene.
作者信息
Yesavage J A, Tanke E D, Sheikh J I
机构信息
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, CA 94305.
出版信息
Arch Gen Psychiatry. 1987 Oct;44(10):913-5. doi: 10.1001/archpsyc.1987.01800220085012.
The purpose of this investigation was to determine the relationship between serum levels of the neuroleptic agent thiothixene and tardive dyskinesia in schizophrenics of a wide age range. Forty-one male schizophrenic subjects, 21 with tardive dyskinesia and 20 without, were given a fixed dosage of thiothixene hydrochloride (10 mg orally four times daily) after a drug-free period of one week. Higher steady-state serum levels of thiothixene (obtained after five days of a fixed-dosage schedule) were associated with greater degrees of tardive dyskinesia. This relationship was independent of the relationship between tardive dyskinesia and age.
本研究的目的是确定在年龄范围广泛的精神分裂症患者中，抗精神病药物硫利达嗪的血清水平与迟发性运动障碍之间的关系。41名男性精神分裂症患者，其中21名患有迟发性运动障碍，20名未患迟发性运动障碍，在停药一周后给予固定剂量的盐酸硫利达嗪（每日口服4次，每次10mg）。硫利达嗪的较高稳态血清水平（在固定剂量给药方案5天后测得）与更严重程度的迟发性运动障碍相关。这种关系独立于迟发性运动障碍与年龄之间的关系。
Zotero 插件