Xiang Zheng, Tu Wenwei
Li Ka Shing Faculty of Medicine, Department of Paediatrics and Adolescent Medicine, Laboratory for Translational Immunology, University of Hong Kong, Hong Kong, Hong Kong.
Front Immunol. 2017 Aug 28;8:1041. doi: 10.3389/fimmu.2017.01041. eCollection 2017.
Vγ9Vδ2-T cells are considered as potent effector cells for tumor immunotherapy through directly killing tumor cells and indirectly regulating other innate and adaptive immune cells to establish antitumoral immunity. The antitumoral activity of Vγ9Vδ2-T cells is governed by a complicated set of activating and inhibitory cell receptors. In addition, cytokine milieu in tumor microenvironment can also induce the pro-tumoral activities and functional plasticity of Vγ9Vδ2-T cells. Here, we review the anti- versus pro-tumoral activities of Vγ9Vδ2-T cells and discuss the mechanisms underlying the recognition, activation, differentiation and regulation of Vγ9Vδ2-T cells in tumor immunosurveillance. The comprehensive understanding of the dual face of Vγ9Vδ2-T cells in tumor immunology may improve the therapeutic efficacy and clinical outcomes of Vγ9Vδ2-T cell-based tumor immunotherapy.
Vγ9Vδ2-T细胞被认为是肿瘤免疫治疗的有效效应细胞，可通过直接杀伤肿瘤细胞和间接调节其他固有免疫细胞及适应性免疫细胞来建立抗肿瘤免疫。Vγ9Vδ2-T细胞的抗肿瘤活性受一系列复杂的激活和抑制性细胞受体调控。此外，肿瘤微环境中的细胞因子环境也可诱导Vγ9Vδ2-T细胞的促肿瘤活性和功能可塑性。在此，我们综述了Vγ9Vδ2-T细胞的抗肿瘤与促肿瘤活性，并讨论了肿瘤免疫监视中Vγ9Vδ2-T细胞识别、激活、分化和调节的潜在机制。全面了解Vγ9Vδ2-T细胞在肿瘤免疫学中的两面性，可能会提高基于Vγ9Vδ2-T细胞的肿瘤免疫治疗的疗效和临床结果。
