在通过暴露于N-甲基-N'-硝基-N-亚硝基胍而转化的C3H 10T1/2细胞中Ha-ras基因的激活。
Activation of the Ha-ras gene in C3H 10T1/2 cells transformed by exposure to N-methyl-N'-nitro-N-nitrosoguanidine.
作者信息
Smith G J, Grisham J W
机构信息
Department of Pathology, University of North Carolina, Chapel Hill 27514.
出版信息
Biochem Biophys Res Commun. 1987 Sep 30;147(3):1194-9. doi: 10.1016/s0006-291x(87)80196-1.
PMID:2889455
Abstract
A transfectable, presumably mutationally activated, c-Ha-ras gene was identified in a clonal population of 10T1/2 cells established from a Type II focus induced by exposure of a parental, wild-type population to N-methyl-N'-nitro-N-nitrosoguanidine (MNNG).
摘要
在一个克隆的10T1/2细胞群体中鉴定出一个可转染的、推测发生了突变激活的c-Ha-ras基因，该细胞群体是由亲代野生型群体暴露于N-甲基-N'-硝基-N-亚硝基胍（MNNG）诱导产生的II型病灶所建立的。
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