Roshanaei Ghodratollah, Sabouri Ghannad Masoud, Poorolajal Jalal, Mohraz Minoo, Molaeipoor Leila
Modeling of Noncommunicable Diseases Research Center, Dept. of Biostatistics and Epidemiology, School of Public Health, Hamadan University of Medical Sciences, Hamadan, Iran.
Research Center for Molecular Medicine, Dept. of Microbiology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
Iran J Public Health. 2017 Aug;46(8):1123-1131.
The number of deaths related with co-infection of tuberculosis (TB) and HIV remains inappropriately high worldwide. TB is anticipated to be the major reason of HIV-related deaths globally. This study aimed to find out and evaluate the characteristics of the possible risk factors influencing the survival time of co-infected patients with HIV/TB in Tehran the capital of Iran.
This retrospective study was performed on the referred patients to the one of two Behavioral Diseases Counseling Centers, Imam Khomeini, and Zamzam Centers, Tehran, Iran, in 2004-2013. Data were analyzed by Cox PH model utilizing SPSS16 statistical software.
Multivariate analysis confirmed that the age at diagnosis (P=0.014), gender (P=0.002), sexual transmission (P=0.01), cotrimoxazole preventive therapy (P<0.001), and onset to TB after post-HIV diagnosis (P=0.01) were the parameters which had significant effects on the death of HIV/TBco-infected patients.
The results, recommend interplay between different risk factors and the risk of death in co-infected patients with HIV/TB. We presented the barriers to higher-level organizational and functional integration for commitment to interfere with the modifiable risk factors, which effect on the mortality of patients.
在全球范围内，与结核病（TB）和艾滋病毒合并感染相关的死亡人数仍然高得不合常理。预计结核病将成为全球艾滋病毒相关死亡的主要原因。本研究旨在找出并评估影响伊朗首都德黑兰艾滋病毒/结核病合并感染患者生存时间的潜在风险因素的特征。
这项回顾性研究针对2004年至2013年转诊至伊朗德黑兰伊玛目霍梅尼和扎姆扎姆两个行为疾病咨询中心之一的患者进行。利用SPSS16统计软件通过Cox PH模型分析数据。
多变量分析证实，诊断时的年龄（P = 0.014）、性别（P = 0.002）、性传播（P = 0.01）、复方新诺明预防性治疗（P < 0.001）以及艾滋病毒诊断后发生结核病的时间（P = 0.01）是对艾滋病毒/结核病合并感染患者死亡有显著影响的参数。
结果表明，不同风险因素之间存在相互作用以及艾滋病毒/结核病合并感染患者的死亡风险。我们提出了在更高层面的组织和功能整合方面存在的障碍，以致力于干预可改变的风险因素，这些因素会影响患者的死亡率。
