内脏脂肪组织作为慢性胰腺炎患者患糖尿病的危险因素：一项横断面观察性研究。
Visceral Adipose Tissue as a Risk Factor for Diabetes Mellitus in Patients with Chronic Pancreatitis: A Cross-sectional, Observational Study.
作者信息
Kumar K V S Hari, Sharma Rahul, Manrai Manish, Sood A K
机构信息
Department of Endocrinology, Army Hospital (R&R), Delhi, India.
Department of Gastroenterology, Army Hospital (R&R), Delhi, India.
出版信息
Diabetes Ther. 2017 Oct;8(5):1057-1064. doi: 10.1007/s13300-017-0304-1. Epub 2017 Sep 11.
INTRODUCTION
Visceral adipose tissue (VAT) is a risk factor for diabetes and we investigated the amount of VAT in patients with chronic pancreatitis (CP).
METHODS
Serial patients with CP seen between January 2015 and June 2016 were included in this cross-sectional, observational study. The study population was divided into alcoholic CP (group 1; N = 67) and tropical CP (group 2; N = 35). VAT was estimated using bioelectric impedance analysis (BIA) and dual energy X-ray absorptiometry (DEXA) methods. The results were analyzed by appropriate statistical methods.
RESULTS
The study participants (85 male, 17 female) had a mean (SD) age of 40.8 (12.6) years, CP duration of 3.7 (4.7) years, and body mass index of 22.5 (3.2) kg/m. Pancreatogenic diabetes was seen in 54 patients and the total body fat percentage was lower in the alcoholic CP group. VAT mass was similar in both the groups (p = 0.8749). CP patients with diabetes had a higher VAT mass (436 vs. 341 g) than those without diabetes (p = 0.0132). DEXA and BIA correlated in estimation of total body fat (p < 0.0001) but not in VAT (p = 0.0922).
CONCLUSION
VAT is a determinant in the development of diabetes, even in patients with CP. DEXA is a better modality for VAT estimation in comparison to BIA.
引言
内脏脂肪组织（VAT）是糖尿病的一个危险因素，我们对慢性胰腺炎（CP）患者的VAT量进行了研究。
方法
本横断面观察性研究纳入了2015年1月至2016年6月期间连续就诊的CP患者。研究人群分为酒精性CP组（第1组；N = 67）和热带性CP组（第2组；N = 35）。使用生物电阻抗分析（BIA）和双能X线吸收法（DEXA）估算VAT。采用适当的统计方法分析结果。
结果
研究参与者（85名男性，17名女性）的平均（标准差）年龄为40.8（12.6）岁，CP病程为3.7（4.7）年，体重指数为22.5（3.2）kg/m²。54例患者出现胰腺性糖尿病，酒精性CP组的全身脂肪百分比更低。两组的VAT质量相似（p = 0.8749）。患有糖尿病的CP患者的VAT质量（436克对341克）高于未患糖尿病的患者（p = 0.0132）。DEXA和BIA在估算全身脂肪方面具有相关性（p < 0.0001），但在估算VAT方面无相关性（p = 0.0922）。
结论
即使在CP患者中，VAT也是糖尿病发生的一个决定因素。与BIA相比，DEXA是估算VAT的更好方法。
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