Department of Otolaryngology, University of Miami Miller School of Medicine, Miami, Florida, U.S.A.
Department of Surgical Oncology, National Cancer Institute, Cairo University, Cairo, Egypt.
Laryngoscope. 2018 May;128(5):1052-1056. doi: 10.1002/lary.26853. Epub 2017 Sep 12.
OBJECTIVES/HYPOTHESIS: To characterize outcomes for patients who underwent transoral microsurgery with potassium titanyl phosphate (KTP) laser resection of early glottic cancers and to compare outcomes with patients who received external beam radiation therapy.
Retrospective cohort study.
The history of patients with T1 glottic carcinoma treated with curative primary radiation or transoral KTP laser resection was reviewed. Oncologic outcomes for both radiation and surgery cohorts including disease-free and overall survival were calculated.
Eighty-seven patients met inclusion criteria from 2011 to 2016; 47 patients (54%) received primary KTP laser ablation, and 40 patients (46%) received primary external beam radiotherapy. The average length of follow-up was 924 ± 529 days in the KTP laser group and 994 ± 603 days in the radiation group (P = .26). There were no significant differences between the two treatment groups in terms of medical or demographic variables. There were six recurrences in the KTP laser group (13%), versus six in the radiotherapy group (15%) (P = .77). The laryngeal preservation rate for the cohort of patients who initially received KTP laser treatment was 46 out of 47 patients (98%). Of the cohort that received primary radiation therapy, the laryngeal preservation rate was 36 out of 40 patients (90%, P = .18). Disease-free and overall survival were 88% and 98% in the KTP laser cohort and 85% and 95% in the radiation cohort (P = .78, P = .56), respectively.
KTP laser ablation is a modality equivalent to primary radiation therapy in oncologic outcomes for T1 glottic squamous cell carcinoma.
目的/假设：描述接受经口微创手术联合磷酸钛钾（KTP）激光治疗早期声门型癌症患者的治疗效果，并与接受外部束放射治疗的患者的治疗效果进行比较。
回顾性队列研究。
回顾 2011 年至 2016 年间接受根治性原发放疗或经口 KTP 激光切除术治疗的 T1 声门型癌患者的病史。计算两组的肿瘤学结果，包括无病生存率和总生存率。
从 2011 年至 2016 年共有 87 名患者符合纳入标准；其中 47 名患者（54%）接受了原发性 KTP 激光消融治疗，40 名患者（46%）接受了原发性外部束放射治疗。KTP 激光组的平均随访时间为 924 ± 529 天，放射组为 994 ± 603 天（P =.26）。两组在医疗或人口统计学变量方面无显著差异。KTP 激光组有 6 例复发（13%），放射组有 6 例复发（15%）（P =.77）。最初接受 KTP 激光治疗的患者中，喉保留率为 47 例中的 46 例（98%）。接受原发性放射治疗的患者中，喉保留率为 40 例中的 36 例（90%，P =.18）。KTP 激光组的无病生存率和总生存率分别为 88%和 98%，放射组分别为 85%和 95%（P =.78，P =.56）。
KTP 激光消融在 T1 声门型鳞状细胞癌的肿瘤学结果方面与原发性放射治疗等效。
4.《喉镜》，128：1052-1056，2018。
