Datta C, Sengupta T, Dasgupta J, Saha U, De K, Sengupta D
Department of Biochemistry, University College of Science, University of Calcutta, India.
Int J Fertil. 1987 Sep-Oct;32(5):380-3.
The activities of different testicular enzymes, as a marker of development, have been determined at various gestational ages. The enzyme sorbitol dehydrogenase shows peak activity between 25 and 28 weeks of gestation, whereas the peak of hyaluronidase was observed between 14 and 16 weeks of gestation. The activities of pentose phosphate enzymes, such as glucose-6-phosphate dehydrogenase and transketolase in developing human fetus reach the highest level between 25 and 28 weeks and 21 and 24 weeks of gestation, respectively, indicating the most actively synthesizing period of the fetus for providing NADPH and ribose-5-phosphate for steroidogenesis and nucleotide and nucleic acid synthesis.
作为发育标志，已测定不同胎龄时睾丸中各种酶的活性。山梨醇脱氢酶在妊娠25至28周之间显示出峰值活性，而透明质酸酶的峰值则在妊娠14至16周之间观察到。发育中的人类胎儿中磷酸戊糖途径的酶，如葡萄糖-6-磷酸脱氢酶和转酮醇酶的活性，分别在妊娠25至28周和21至24周之间达到最高水平，这表明胎儿为类固醇生成以及核苷酸和核酸合成提供NADPH和5-磷酸核糖的最活跃合成期。
