Takai S, Tateishi H, Nishisho I, Miki T, Motomura K, Miyauchi A, Kato M, Ikeuchi T, Yamamoto K, Okazaki M
Second Department of Surgery, Osaka University Medical School.
Jpn J Cancer Res. 1987 Sep;78(9):894-8.
Using polymorphic DNA markers, we compared the constitutional and tumor genotypes of patients with multiple endocrine neoplasia type 2A (MEN2 A). We found loss of constitutional heterozygosity at the D22S9 locus in one out of 9 medullary thyroid carcinomas (MTCs). No loss of heterozygosity was detected at 12 other loci in any of the MTCs tested. Loss of heterozygosity at D22S9 and/or D22S1 was also demonstrated in 2 out of 5 pheochromocytomas tested. These results suggest that loss or mutation of a gene on chromosome 22 may play an important role in tumorigenesis in MEN2A.
我们使用多态性DNA标记，比较了2A型多发性内分泌腺瘤病（MEN2 A）患者的体质基因型和肿瘤基因型。我们在9例甲状腺髓样癌（MTC）中的1例中发现D22S9位点的体质杂合性缺失。在所检测的任何MTC中，在其他12个位点均未检测到杂合性缺失。在5例所检测的嗜铬细胞瘤中的2例中也证实了D22S9和/或D22S1位点的杂合性缺失。这些结果表明，22号染色体上一个基因的缺失或突变可能在MEN2A的肿瘤发生中起重要作用。
