Grulliero A, Luglio A, Antonelli F, Parascandolo S, Bifano A, Perna G
Minerva Stomatol. 1979 Jan-Mar;28(1):49-51.
1-2 g/day or 3-4 g/day phosphomycin were administered per os to children and adults respectively for an average of 5.2 days in the outpatient treatment of 28 males and 18 females with parodontitis, gingivitis and dysodontiasis of bacterial origin. All patients presented swelling of the soft parts and 34 (74%) had hyperpyrexia. A clinical cure was obtained after 9 days in all cases. Fever lasted an average of 2.4 days and disappeared after 6 days. Swelling lasted an average of 3.6 days and disappeared after 8 days. Tolerance was excellent. Two patients (4.3%) displayed diarrhoea and nausea and one (2.2%) pruritus. These side-effects did not necessitate the suspension of treatment. It is felt that phosphomycin may be regarded as a drug of choice in the treatment of odontostomatological infection of bacterial origin.
在对28名男性和18名女性因细菌感染引起的牙周炎、牙龈炎和牙病进行门诊治疗时，分别对儿童和成人口服给予每日1 - 2克或每日3 - 4克的磷霉素，平均用药5.2天。所有患者均出现软组织肿胀，34例（74%）有高热。所有病例在9天后均获得临床治愈。发热平均持续2.4天，6天后消失。肿胀平均持续3.6天，8天后消失。耐受性良好。两名患者（4.3%）出现腹泻和恶心，一名患者（2.2%）出现瘙痒。这些副作用并不需要中止治疗。人们认为磷霉素可被视为治疗细菌感染性口腔疾病的首选药物。
