Institut für Medizinische Mikrobiologie, Virologie und Hygiene, University Medical Center Eppendorf, Martinistr. 52, 20246 Hamburg, Germany.
Dev Cell. 2017 Sep 11;42(5):436-438. doi: 10.1016/j.devcel.2017.08.018.
The Arp2/3 complex nucleates branched actin networks and is thought to be essential for macrophage migration and phagocytosis. In this issue of Developmental Cell, Rotty et al. (2017) show that there is only a surprisingly specific requirement for Arp2/3 in integrin-dependent macrophage functions, including CR3 phagocytosis and haptotaxis on fibronectin.
Arp2/3 复合物能够引发分支状肌动蛋白网络的形成，被认为是巨噬细胞迁移和吞噬作用所必需的。在本期《发育细胞》中，Rotty 等人（2017）表明，Arp2/3 对于整合素依赖性的巨噬细胞功能，包括 CR3 吞噬作用和在纤维连接蛋白上的趋化性，仅有出人意料的特定需求。
