Gungoren Fatih, Senturk Tunay, Ozturk Alper, Koz Kerem, Sarandol Emre, Yesilbursa Dilek, Gullulu Sumeyye, Ozkaya Guven, Aydinlar Ali
a Department of Cardiology, Faculty of Medicine , Uludag University , Bursa , Turkey.
b Department of Clinical Biochemistry, Faculty of Medicine , Uludag University , Bursa , Turkey.
Acta Cardiol. 2018 Feb;73(1):85-90. doi: 10.1080/00015385.2017.1351237. Epub 2017 Sep 12.
This study examined whether the serum PON1 activity is different in patients with ischaemic dilated cardiomyopathy (IDCM) and nonischaemic dilated cardiomyopathy (NDCM) and the relation between the serum PON1 activity and serum pro-BNP levels.
In this study, we enrolled 60 patients with left ventricular systolic failure (New York Heart Association [NYHA] class III-IV) and a left ventricular ejection fraction (EF) < 40% as determined by echocardiography and 30 healthy subjects. The patients with systolic heart failure were divided into two groups: patients with IDCM and patients with NDCM. Blood samples were obtained to measure the serum PON1 activity and the serum pro-BNP levels. The median serum PON1 activities were lower among the patients with IDCM or with NDCM compared with the control subjects (p < .001, p = .043, respectively). Compared with the control subjects, the patients with IDCM or with NDCM had higher serum pro-BNP levels (p < .001, p < .001, respectively). The serum PON1 activity was negatively correlated with the serum pro-BNP levels in patients with IDCM (r = -0.548, p < .001). The area under the ROC curve of the serum PON1 activity was 0.798. Using a serum PON1 activity of 201.3 U/L as a cut-off value, the sensitivity was 86.84% and specificity was 66.67% for the diagnosis of IDCM.
In this study, the serum PON1 activity was significantly reduced in the patients with IDCM or with NDCM compared with the control subjects. The serum PON1 activity of the patients with IDCM was negatively correlated with the serum pro-BNP levels.
本研究旨在探讨缺血性扩张型心肌病（IDCM）患者和非缺血性扩张型心肌病（NDCM）患者的血清对氧磷酶1（PON1）活性是否存在差异，以及血清PON1活性与血清脑钠肽前体（pro-BNP）水平之间的关系。
本研究纳入了60例左心室收缩功能衰竭（纽约心脏协会[NYHA]心功能分级III-IV级）且经超声心动图测定左心室射血分数（EF）<40%的患者以及30名健康受试者。收缩性心力衰竭患者被分为两组：IDCM患者和NDCM患者。采集血样以测定血清PON1活性和血清pro-BNP水平。与对照组相比，IDCM患者和NDCM患者的血清PON1活性中位数较低（分别为p<0.001，p=0.043）。与对照组相比，IDCM患者和NDCM患者的血清pro-BNP水平较高（分别为p<0.001，p<0.001）。IDCM患者的血清PON1活性与血清pro-BNP水平呈负相关（r=-0.548，p<0.001）。血清PON1活性的ROC曲线下面积为0.798。以血清PON1活性201.3 U/L作为截断值，诊断IDCM的敏感性为86.84%，特异性为66.67%。
在本研究中，与对照组相比，IDCM患者和NDCM患者的血清PON1活性显著降低。IDCM患者的血清PON1活性与血清pro-BNP水平呈负相关。
