机械清创术联合或不联合辅助抗菌光动力疗法治疗糖尿病前期患者牙周炎的疗效。
Effectiveness of mechanical debridement with and without adjunct antimicrobial photodynamic therapy in the treatment of periodontal inflammation among patients with prediabetes.
机构信息
Department of Periodontology, College of Dentistry, King Saud University, Riyadh, Saudi Arabia.
Dental Biomaterials Research Chair, Dental Health Department, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia.
出版信息
Photodiagnosis Photodyn Ther. 2017 Dec;20:91-94. doi: 10.1016/j.pdpdt.2017.09.005. Epub 2017 Sep 9.
AIM
The aim of the present study was to assess the effectiveness of mechanical debridement (MD) with and without adjunct antimicrobial photodynamic therapy (aPDT) in the treatment of periodontal inflammation among patients with prediabetes.
METHODS
Demographic information was collected using a questionnaire. Hemoglobin A1c (HbA1c) levels were measured at baseline and at 3 and 6 months' follow-up.
TREATMENT
Individuals were randomly divided into 2 groups as follows: (a) Group-1, participants underwent full-mouth MD; and Group-2: participants underwent full-mouth MD with adjunct aPDT. In groups 1 and 2, full-mouth plaque index (PI), bleeding on probing (BOP) and probing pocket depth (PPD) were measured at baseline and at 3 and 6 months' follow-up. In both groups, full-mouth digital intraoral radiographs were also taken. Sample-size was estimated and statistical analysis was performed with level of significance set as P<0.05.
RESULTS
In total, 70 prediabetic male individuals (35 patients in group-1 and 35 in group-2) were included. At baseline, PI, BOP, number of sites with PPD ≥4mm were comparable among individuals in groups 1 and 2. In groups 1 and 2, PI (P<0.05), BOP (P<0.05), number of sites with PPD ≥4mm (P<0.05) were significantly higher at baseline compared with 3 months' follow-up. There was no statistically significant difference in PI, BOP, number of sites with PPD ≥4mm at 3 and 6 months' follow-up. At 6 months' follow-up, PI, BOP, number of sites with PPD ≥4mm were comparable to their respective baseline values. There was no statistically significant difference in CBL in both groups at 3 and 6 months' follow-up. There was no statistically significant difference in HbA1c levels among individuals in groups 1 and 2 at all-time intervals.
CONCLUSION
In the short-term, MD is effective in reducing periodontal inflammation among patients with prediabetes. The contribution of adjunct aPDT in this regard is insignificant.
目的
本研究旨在评估机械清创（MD）联合和不联合辅助抗菌光动力疗法（aPDT）在治疗糖尿病前期患者牙周炎中的疗效。
方法
采用问卷收集人口统计学信息。在基线和 3 个月及 6 个月随访时测量血红蛋白 A1c（HbA1c）水平。
治疗
将个体随机分为 2 组：（a）组 1，参与者接受全口 MD；组 2：参与者接受全口 MD 联合辅助 aPDT。在组 1 和 2 中，在基线以及 3 个月和 6 个月随访时测量全口菌斑指数（PI）、探诊出血（BOP）和探诊牙周袋深度（PPD）。在两组中，还拍摄了全口数字化口腔内 X 光片。估计了样本量，并设置了显著性水平 P<0.05 进行了统计分析。
结果
共有 70 名糖尿病前期男性个体（组 1 中 35 名患者，组 2 中 35 名患者）入选。在基线时，组 1 和组 2 中个体的 PI、BOP、PPD≥4mm 的位点数量无差异。在组 1 和组 2 中，PI（P<0.05）、BOP（P<0.05）、PPD≥4mm 的位点数量（P<0.05）在基线时均显著高于 3 个月随访时。在 3 个月和 6 个月随访时，PI、BOP、PPD≥4mm 的位点数量无统计学差异。在 6 个月随访时，PI、BOP、PPD≥4mm 的位点数量与各自的基线值相当。在 3 个月和 6 个月随访时，两组的 CBL 无统计学差异。在所有时间点，组 1 和组 2 中个体的 HbA1c 水平无统计学差异。
结论
短期内，MD 可有效减轻糖尿病前期患者的牙周炎。辅助 aPDT 的作用并不显著。
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