Evidence for a Role of ANAC082 as a Ribosomal Stress Response Mediator Leading to Growth Defects and Developmental Alterations in Arabidopsis.

Ribosome-related mutants in share several notable characteristics regarding growth and development, which implies the existence of a common pathway that responds to disorders in ribosome biogenesis. As a first step to explore this pathway genetically, we screened a mutagenized population of (), a temperature-sensitive mutant that is impaired in pre-rRNA processing, and isolated (), a suppressor mutant in which the defects of cell proliferation observed in at the restrictive temperature was markedly rescued. was identified as a missense mutation of the NAC transcription factor gene The mutation greatly alleviated the developmental abnormalities of and four other tested ribosome-related mutants, including However, the impaired pre-rRNA processing in and was not relieved by Expression of was localized to regions where phenotypic effects of ribosome-related mutations are readily evident and was elevated in and compared with the wild type. These findings suggest that ANAC082 acts downstream of perturbation of biogenesis of the ribosome and may mediate a set of stress responses leading to developmental alterations and cell proliferation defects.