Boudaouara Ons, Chaari Chiraz, Hassini Abdelkhalek, Boudaouara Tahya Sellami
Department of Pathology, Habib Bourguiba University Hospital, Sfax, Tunisia.
Indian J Med Paediatr Oncol. 2017 Apr-Jun;38(2):223-225. doi: 10.4103/ijmpo.ijmpo_115_16.
Mammary myofibroblastoma (MFB) is a rare mesenchymal tumor, derived from mammary stromal fibro/myofibroblasts, which has various morphological features and characteristic immunohistochemical staining. The epithelioid morphologic variant is defined, accordingly, as a proliferation of exclusively or predominantly (>50%) epithelioid cells, variably embedded in a myxoid to fibrous stroma. These histological and cytological features may pose a diagnostic challenge mainly with metaplastic carcinoma and invasive lobular carcinoma of the breast. Thus, immunohistochemical staining by myofibroblastic markers is helpful for confirming diagnosis. Herein, we present a case of MFB in a 43-year-old female. This case report emphasizes the role of immunohistochemistry as gold standard in the diagnosis of MFB. This case is also being presented because of its unusual radiologic findings, its epithelioid histologic variant mimicking malignancy, and its uncommon immunohistochemical phenotype.
乳腺肌纤维母细胞瘤（MFB）是一种罕见的间叶组织肿瘤，起源于乳腺间质纤维母/肌纤维母细胞，具有多种形态学特征和特征性免疫组化染色。因此，上皮样形态学变异型被定义为完全或主要（>50%）由上皮样细胞构成的增殖，这些细胞可变地嵌入黏液样至纤维性间质中。这些组织学和细胞学特征主要在乳腺化生性癌和浸润性小叶癌的诊断中可能构成挑战。因此，采用肌纤维母细胞标志物进行免疫组化染色有助于确诊。在此，我们报告一例43岁女性的MFB病例。本病例报告强调了免疫组化作为MFB诊断金标准的作用。报告此病例还因其不寻常的影像学表现、类似恶性肿瘤的上皮样组织学变异型以及不常见的免疫组化表型。
