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表皮生长因子对酪氨酸羟化酶基因的调控表达

Regulated expression of the tyrosine hydroxylase gene by epidermal growth factor.

作者信息

Lewis E J, Chikaraishi D M

机构信息

Neuroscience Program, Tufts University School of Medicine, Boston, Massachusetts 02111.

出版信息

Mol Cell Biol. 1987 Sep;7(9):3332-6. doi: 10.1128/mcb.7.9.3332-3336.1987.

DOI:10.1128/mcb.7.9.3332-3336.1987
PMID:2890099
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC367973/
Abstract

The addition of epidermal growth factor (EGF) to cultures of the rat PCG2 pheochromocytoma cell line increased the level of RNA coding for tyrosine hydroxylase (TH). A region of DNA containing 5'-flanking sequences of the TH gene was fused to a heterologous gene and transfected into a rat anterior pituitary cell line, GH4. The TH gene sequences from +27 to -272 contained information sufficient for the induction of TH by EGF. Two regions within this TH DNA were extensively homologous to the EGF regulatory element of the rat prolactin gene.

摘要

向大鼠嗜铬细胞瘤细胞系PCG2的培养物中添加表皮生长因子（EGF），可增加编码酪氨酸羟化酶（TH）的RNA水平。将包含TH基因5'侧翼序列的一段DNA区域与一个异源基因融合，并转染到大鼠垂体前叶细胞系GH4中。TH基因从+27至 -272的序列包含足以被EGF诱导TH的信息。该TH DNA内的两个区域与大鼠催乳素基因的EGF调节元件高度同源。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c0b/367973/20292967bfe3/molcellb00081-0317-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c0b/367973/20292967bfe3/molcellb00081-0317-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c0b/367973/20292967bfe3/molcellb00081-0317-a.jpg

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引用本文的文献

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Regulation of tyrosine hydroxylase gene expression during transdifferentiation of striatal neurons: changes in transcription factors binding the AP-1 site.纹状体神经元转分化过程中酪氨酸羟化酶基因表达的调控：与AP-1位点结合的转录因子的变化

本文引用的文献

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Epidermal growth factor rapidly stimulates prolactin gene transcription.表皮生长因子迅速刺激催乳素基因转录。
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Polyadenylylated RNA complementary to a mouse retrovirus-like multigene family is rapidly and specifically induced by epidermal growth factor stimulation of quiescent cells.与小鼠逆转录病毒样多基因家族互补的聚腺苷酸化RNA在静止细胞受到表皮生长因子刺激后被快速且特异性地诱导产生。
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