Feng Yuhua, Zhong Meizuo, Liu Yiping, Wang Leyuan, Tang Youhong
Department of Oncology, Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.
Department of Pediatrics, Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.
Histol Histopathol. 2018 Mar;33(3):307-315. doi: 10.14670/HH-11-931. Epub 2017 Sep 13.
To investigate the expression of TIM-3 and LAG-3 in extranodal NK/T cell lymphoma, nasal type (ENKTL), and evaluate the clinical and prognostic significance of TIM-3 and LAG-3 in ENKTL.
A total of 61 human paraffin-embedded specimens including 41 ENKTL and 20 rhinitis were involved. We performed immunohistochemistry to detect the expression of TIM-3 and LAG-3. We analyzed correlation between expression of TIM-3 and LAG-3 and clinicopathological features of ENKTL.
TIM-3 was positively expressed in 95 (39/41) ENKTL compared with 55% (11/20) in rhinitis, LAG-3 was positively expressed in 95 (39/41) ENKTL compared with 45% (9/20) in rhinitis. A positive correlation was found between TIM-3 and LAG-3. TIM-3 and LAG-3 had no significant correlation with ENKTL patients' age, gender, international prognostic index (IPI) score, B symptoms, LDH level, Ann Arbor stage and treatment regimens. High expression of TIM-3, high IPI score, elevated LDH level and late Ann Arbor stage were shown to be correlated with worse progression free survival (PFS). A multivariate COX regression model show that TIM-3 high expression rate was an independent prognostic factor for ENKTL patients' PFS.
Our findings indicate that TIM-3 might be a promising predictive indicator for the ENKTL patients.
探讨T细胞免疫球蛋白黏蛋白分子3（TIM-3）和淋巴细胞活化基因3（LAG-3）在鼻型结外NK/T细胞淋巴瘤（ENKTL）中的表达情况，并评估TIM-3和LAG-3在ENKTL中的临床及预后意义。
共纳入61例人石蜡包埋标本，其中包括41例ENKTL和20例鼻炎标本。我们采用免疫组织化学法检测TIM-3和LAG-3的表达。分析TIM-3和LAG-3的表达与ENKTL临床病理特征之间的相关性。
TIM-3在95%（39/41）的ENKTL中呈阳性表达，而在鼻炎中为55%（11/20）；LAG-3在95%（39/41）的ENKTL中呈阳性表达，而在鼻炎中为45%（9/20）。TIM-3与LAG-3之间存在正相关。TIM-3和LAG-3与ENKTL患者的年龄、性别、国际预后指数（IPI）评分、B症状、乳酸脱氢酶（LDH）水平、Ann Arbor分期及治疗方案均无显著相关性。TIM-3高表达、高IPI评分、LDH水平升高及Ann Arbor晚期与无进展生存期（PFS）较差相关。多因素COX回归模型显示，TIM-3高表达率是ENKTL患者PFS的独立预后因素。
我们的研究结果表明，TIM-3可能是ENKTL患者一个有前景的预测指标。
