Price Jonathan, Clarke Nicholas, Turer Aslan, Quintana Eduard, Mestres Carlos, Huffman Lynn, Peltz Matthias, Wait Michael, Ring W Steves, Jessen Michael, Bajona Pietro
1 Department of Cardiovascular and Thoracic Surgery, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
2 Division of Cardiology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Asian Cardiovasc Thorac Ann. 2017 Nov;25(9):594-607. doi: 10.1177/0218492317733111. Epub 2017 Sep 13.
Hypertrophic cardiomyopathy ranks among the most common congenital cardiac diseases, affecting up to 1 in 200 of the general population. When it causes left ventricular outflow tract obstruction, treatment is guided to reduce symptoms and the risk of sudden cardiac death. Pharmacologic therapy is the first-line treatment, but when it fails, surgical myectomy or percutaneous ablation of the hypertrophic myocardium are the standard therapies to eliminate subaortic obstruction. Both surgical myectomy and percutaneous ablation are proven safe and effective treatments; however, myectomy is the gold standard with a significantly lower complication rate and more complete and lasting reduction of left ventricular outflow tract obstruction.
肥厚型心肌病是最常见的先天性心脏病之一，在普通人群中的发病率高达二百分之一。当它导致左心室流出道梗阻时，治疗旨在减轻症状并降低心源性猝死风险。药物治疗是一线治疗方法，但治疗失败时，外科心肌切除术或经皮肥厚心肌消融术是消除主动脉瓣下梗阻的标准治疗方法。外科心肌切除术和经皮消融术均被证明是安全有效的治疗方法；然而，心肌切除术是金标准，其并发症发生率显著更低，能更完全且持久地减轻左心室流出道梗阻。
