噻唑衍生物的合成化学及其抗菌重要性综述
Review on Synthetic Chemistry and Antibacterial Importance of Thiazole Derivatives.
作者信息
Kashyap Ankita, Adhikari Nayana, Das Arpita, Shakya Anshul, Ghosh Surajit Kumar, Singh Udaya Pratap, Bhat Hans Raj
机构信息
Department of Pharmaceutical Sciences, School of Science and Engineering, Dibrugarh University, Dibrugarh - 786 004, Assam, India.
Drug Design & Discovery Laboratory, Department of Pharmaceutical Sciences, Sam Higginbottom University of Agriculture, Technology & Science, Allahabad 211007, India.
出版信息
Curr Drug Discov Technol. 2018;15(3):214-228. doi: 10.2174/1570163814666170911144036.
BACKGROUND
Thiazole is one of the leading heterocyclic five-member ring compounds that contain nitrogen and sulphur atom. Many natural and/or synthetic compounds contain thiazole as an essential moiety and possess diverse therapeutic activities. The thiazole ring was modified at different positions to generate new molecules with potent antibacterial activities. Thus, the present review enumerates the antibacterial importance of thiazole and its derivatives.
METHOD
The mining of literature has been performed using different database which includes only peer-reviewed journals. The quality of retrieved papers was appraised using standard tools. Moreover, the significant papers were described in detail to focus on thiazole derivatives showing considerable antibacterial activity.
RESULT
The present review describes the chemistry, SAR (Structure Activity Relationship) studies and antibacterial importance of thiazole with different synthetic procedures.
CONCLUSION
This particular study certainly benefits the researchers interested in exploiting the antibacterial activity of thiazoles in search of novel agents.
背景
噻唑是含氮和硫原子的主要杂环五元环化合物之一。许多天然和/或合成化合物含有噻唑作为必需部分，并具有多种治疗活性。噻唑环在不同位置进行修饰以产生具有强效抗菌活性的新分子。因此，本综述列举了噻唑及其衍生物的抗菌重要性。
方法
使用仅包括同行评审期刊的不同数据库进行文献挖掘。使用标准工具评估检索到的论文质量。此外，对重要论文进行了详细描述，以关注显示出相当抗菌活性的噻唑衍生物。
结果
本综述描述了噻唑的化学、构效关系（SAR）研究以及不同合成方法的抗菌重要性。
结论
这项特定研究肯定会使有兴趣利用噻唑抗菌活性寻找新型药物的研究人员受益。
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