Department of Pharmaceutical Chemistry, "Iuliu Hațieganu" University of Medicine and Pharmacy, 41 Victor Babeș Street, 400012 Cluj-Napoca, Romania.
Preclinic Department, Pharmacy Specialization, Faculty of Medicine, Lucian Blaga University of Sibiu, 2A Lucian Blaga Street, 550169 Sibiu, Romania.
Molecules. 2021 Jan 25;26(3):624. doi: 10.3390/molecules26030624.
Thiazole, a five-membered heteroaromatic ring, is an important scaffold of a large number of synthetic compounds. Its diverse pharmacological activity is reflected in many clinically approved thiazole-containing molecules, with an extensive range of biological activities, such as antibacterial, antifungal, antiviral, antihelmintic, antitumor, and anti-inflammatory effects. Due to its significance in the field of medicinal chemistry, numerous biologically active thiazole and bisthiazole derivatives have been reported in the scientific literature. The current review provides an overview of different methods for the synthesis of thiazole and bisthiazole derivatives and describes various compounds bearing a thiazole and bisthiazole moiety possessing antibacterial, antifungal, antiprotozoal, and antitumor activity, encouraging further research on the discovery of thiazole-containing drugs.
噻唑是一种五元杂环芳香族化合物，是大量合成化合物的重要骨架。其多样的药理活性体现在许多临床批准的含噻唑分子中，具有广泛的生物活性，如抗菌、抗真菌、抗病毒、抗寄生虫、抗肿瘤和抗炎作用。由于其在药物化学领域的重要性，科学文献中报道了许多具有生物活性的噻唑和双噻唑衍生物。本综述概述了合成噻唑和双噻唑衍生物的不同方法，并描述了具有噻唑和双噻唑部分的各种具有抗菌、抗真菌、抗原生动物和抗肿瘤活性的化合物，鼓励进一步研究含噻唑药物的发现。
