Alexiou Athanasios, Soursou Georgia, Yarla Nagendra Sastry, Md Ashraf Ghulam
Novel Global Community Educational Foundation, Hebersham, Australia.
Bioinformatics Graduate Program, Medical School, University of Crete, Heraklion, Greece.
Curr Protein Pept Sci. 2018;19(9):876-880. doi: 10.2174/1389203718666170911145321.
Several years after the first publication of Barker's Hypothesis the identification of common patterns and pathways between genetic and epigenetic risk factors in neurodegenerative disorders is still an open problem. For the cases of Alzheimer's disease and Autism and by taking into consideration the increasing number of diagnosed cases globally, scientists focused on commonly expressed and related proteins like Amyloid beta and the mechanisms of their underlying dysfunctionalities. In this review paper, an attempt to specify significant correlations between proteins linked to Autism Spectrum Disorders and Alzheimer's Disease is presented. Both diseases are highlighted with an emphasis on the macromolecules that play a fundamental role in their development. These proteins are described and analyzed concerning the underlying pathology of these diseases.
在巴克假说首次发表几年后，确定神经退行性疾病中遗传和表观遗传风险因素之间的共同模式和途径仍然是一个悬而未决的问题。对于阿尔茨海默病和自闭症的病例，并考虑到全球诊断病例数量的不断增加，科学家们聚焦于常见表达且相关的蛋白质，如β淀粉样蛋白及其潜在功能失调的机制。在这篇综述论文中，尝试明确与自闭症谱系障碍和阿尔茨海默病相关的蛋白质之间的显著相关性。两种疾病都受到关注，重点强调了在其发展过程中起关键作用的大分子。针对这些疾病的潜在病理学对这些蛋白质进行了描述和分析。
