Niaz Kamal, Maqbool Faheem, Bahadar Haji, Abdollahi Mohammad
International Campus, Tehran University of Medical Sciences (IC-TUMS), Tehran. Iran.
Institute of Paramedical Sciences, Khyber Medical University, Peshawar. Pakistan.
Curr Drug Metab. 2017;18(10):881-892. doi: 10.2174/1389200218666170911152240.
Honey is known for its therapeutic properties from ancient civilizations. Recently, the mechanism of action of Manuka honey in wound healing, epithelial regeneration, and ulcer treatments has been revealed.
In the current review, the health perspectives of honey, its chemical composition with special reference to flavonoids, polyphenol, and other bioactive trace compounds used in tissue regeneration have been discussed in detail.
We undertook a structured search using wide spectrum sources like Google Scholar, PubMed, and Scopus.
The included papers showed that Manuka honey can inhibit the process of carcinogenesis by controlling different molecular processes, and progression of cancer cells. Manuka honey has been found to have various biological activities, including antioxidant, antimicrobial and anti-proliferative capacities. Scientists try to use Manuka honey in the area of tissue engineering to design a template for regeneration. Naturally derived antibacterial agents of Manuka honey are numerous mixtures of different compounds, which can influence antibacterial capacity. The non-peroxide bacteriostatic properties of Manuka honey are associated with the presence of methylglyoxal (MGO).
In addition to bacterial growth inhibition, glyoxal (GO) and MGO from Manuka honey can enhance wound healing and tissue regeneration by their immunomodulatory property. Further studies are needed to provide detailed information about active components of Manuka honey and their potential efficacy in different diseases.
蜂蜜自古代文明以来就因其治疗特性而闻名。最近，麦卢卡蜂蜜在伤口愈合、上皮再生和溃疡治疗方面的作用机制已被揭示。
在当前的综述中，详细讨论了蜂蜜的健康前景、其化学成分，特别提及了用于组织再生的黄酮类化合物、多酚和其他生物活性微量化合物。
我们使用谷歌学术、PubMed和Scopus等广泛的来源进行了结构化搜索。
纳入的论文表明，麦卢卡蜂蜜可以通过控制不同的分子过程和癌细胞的进展来抑制致癌过程。已发现麦卢卡蜂蜜具有多种生物活性，包括抗氧化、抗菌和抗增殖能力。科学家们试图在组织工程领域使用麦卢卡蜂蜜来设计再生模板。麦卢卡蜂蜜的天然抗菌剂是不同化合物的多种混合物，这会影响抗菌能力。麦卢卡蜂蜜的非过氧化物抑菌特性与甲基乙二醛（MGO）的存在有关。
除了抑制细菌生长外，麦卢卡蜂蜜中的乙二醛（GO）和MGO还可以通过其免疫调节特性促进伤口愈合和组织再生。需要进一步的研究来提供关于麦卢卡蜂蜜活性成分及其在不同疾病中潜在功效的详细信息。
