Wang Junjie, Zhang Fujun, Guo Jinhe, Chai Shude, Zheng Guangjun, Zhang Kaixian, Liao Anyan, Jiang Ping, Jiang Yuliang, Ji Zhe
Department of Radiation Oncology, Peking University Third Hospital, Beijing; Chinese North Multi Center Cooperative Group of Particles Radiotherapy Specialized of Beijing Medical Association, Beijing, China.
Department of Medical Imaging, Minimally Invasive Interventional Center, Sun Yat-Sen University Cancer Center, Guangzhou, China.
J Cancer Res Ther. 2017;13(4):607-612. doi: 10.4103/jcrt.JCRT_412_17.
Radioactive 125I seeds (RIS) interstitial implantation brachytherapy has been a first-line treatment for early-stage cancer of the prostate gland. However, its poor accuracy and homogeneity has limited its indication and hampered its popularization for a long time. Intriguingly, scholars based in China introduced computed tomography (CT)-guided technology to improve the accuracy and homogeneity of RIS implantation and broadened the indications. Then, they creatively designed and introduced three-dimensional printing coplanar template (3D-PCT) and 3D printing noncoplanar template (3D-PNCT) into the practice of RIS implantation. Use of such templates makes RIS implantation more precise and efficacious and aids preoperative planning, real-time dose optimization, and postoperative planning. However, studies on the standard workflow for 3D-PT-assisted CT-guided RIS implantation have not been published. Therefore, the China Northern Radioactive Seeds Brachytherapy Group organized multidisciplinary experts to formulate the guideline for this emerging treatment modality. This guideline aims at standardizing 3D-PT-assisted CT-guided RIS implantation procedures and criteria for selecting treatment candidates and assessing outcomes and for preventing and managing postoperative complications.
放射性¹²⁵I粒子（RIS）组织间植入近距离放射治疗一直是早期前列腺癌的一线治疗方法。然而，其准确性和均匀性较差，长期以来限制了其适应证并阻碍了其推广。有趣的是，中国学者引入了计算机断层扫描（CT）引导技术，以提高RIS植入的准确性和均匀性，并扩大了适应证。然后，他们创造性地设计并将三维打印共面模板（3D-PCT）和三维打印非共面模板（3D-PNCT）引入RIS植入实践。使用此类模板可使RIS植入更精确、有效，并有助于术前规划、实时剂量优化和术后规划。然而，关于3D-PT辅助CT引导下RIS植入的标准工作流程的研究尚未发表。因此，中国北方放射性粒子近距离治疗协作组组织多学科专家制定了这种新兴治疗方式的指南。本指南旨在规范3D-PT辅助CT引导下RIS植入程序、治疗候选者的选择标准以及评估结果，并预防和处理术后并发症。
