Annibale B, Delle Fave G, Barbetti F, de Magistris L, Puoti M, Giordano E, Leonetti F, Tamburrano G
I Cattedra di Gastroenterologia, Università degli Studi La Sapienza, Roma, Italy.
Pancreas. 1987;2(5):551-6. doi: 10.1097/00006676-198709000-00010.
The effect of increased doses of Somatostatin-14 (3, 10, 30, 100, 300 micrograms/h) on basal release of insulin, pancreatic glucagon and pancreatic polypeptide (PP) was investigated on eight normal volunteers. Levels of Somatostatin-like immunoreactivity (SLI) was determined in order to correlate the increased SLI levels with the degree of islet hormone inhibition (r = 0.9947, p less than 0.01). By increasing the basal levels of SLI by one-third, a significant inhibition (p less than 0.01) of insulin, glucagon, and PP was noted (78.5, 78.6, 75.2%, respectively, on basal levels). The maximal effect was obtained with 300 micrograms/h for insulin, with 30 micrograms/h for glucagon and 100 micrograms/h for PP. In evaluating the relative inhibitory potency of somatostatin, expressed as ED50, the theoretic potency of somatostatin on each peptide had similar values, ranging from 30 to 10 micrograms/h. The present data show that a minimal peripheric increase in SLI is able to regulate basal islet pancreatic hormones.
在8名正常志愿者身上研究了增加剂量的生长抑素-14（3、10、30、100、300微克/小时）对胰岛素、胰高血糖素和胰多肽（PP）基础释放的影响。测定生长抑素样免疫反应性（SLI）水平，以便将升高的SLI水平与胰岛激素抑制程度相关联（r = 0.9947，p < 0.01）。将SLI基础水平提高三分之一后，观察到胰岛素、胰高血糖素和PP受到显著抑制（p < 0.01）（分别为基础水平的78.5%、78.6%、75.2%）。胰岛素在300微克/小时时达到最大效应，胰高血糖素在30微克/小时时达到最大效应，PP在100微克/小时时达到最大效应。在评估以ED50表示的生长抑素的相对抑制效力时，生长抑素对每种肽的理论效力具有相似的值，范围为30至10微克/小时。目前的数据表明，外周血中SLI的最小增加能够调节胰岛胰腺激素的基础分泌。
