超声辐射下新型双螺吡唑类化合物作为抗肿瘤剂的合成
Synthesis of New Bis-Spiropyrazoles as Antitumor Agents under Ultrasound Irradiation.
作者信息
Abdel Hafez Naglaa A, Hassaneen Huwaida M E, Farghaly Thoraya A, Riyadh Sayed M, Elzahabi Heba S A
机构信息
Department of Applied Organic Chemistry, National Research Center, Dokki, Cairo, Egypt.
Department of Chemistry, Faculty of Science, Cairo University, Giza 12613, Egypt.
出版信息
Mini Rev Med Chem. 2018;18(7):631-637. doi: 10.2174/1389557517666170912170027.
OBJECTIVE AND BACKGROUND
Hydrazonoyl halides were used as precursors for the synthesis of a new series of bis-spiropyrazoles via reaction with 3,5-diarylidene-piperidone derivatives under ultrasound irradiation. The products were secluded in good yield after short reaction periods.
CONCLUSION
The anticancer activity of bis-spiropyrazoles against HepG2 (hepatic cancer), A549 (lung cancer) and CaCo2 (colon cancer) cell lines was screened. Three tested compounds 4b, 4c and 4f showed promising activity.
目的与背景
在超声辐射下，卤代肼基酰卤与3,5-二芳叉基哌啶酮衍生物反应，用作合成一系列新的双螺吡唑的前体。反应时间短，产物以良好的产率分离得到。
结论
筛选了双螺吡唑对HepG2（肝癌）、A549（肺癌）和CaCo2（结肠癌）细胞系的抗癌活性。三种受试化合物4b、4c和4f显示出有前景的活性。
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