School of Pharmacy, Yancheng Teachers University , Yancheng 224051, P. R. China.
ACS Comb Sci. 2014 Mar 10;16(3):139-45. doi: 10.1021/co400096c. Epub 2014 Feb 20.
An efficient and regioselective synthesis of novel functionalized dispiropyrrolizidine derivatives via a three-component [3 + 2] cycloaddition reaction of azomethine ylides is described. This protocol has the advantages of high efficiency, mild reaction conditions, a one-pot procedure, and convenient operation. Many of these compounds were evaluated for their antiproliferative properties in vitro against cancer cells and several compounds were found to have good activities.
描述了一种通过吖丙啶叶立德的三组分[3+2]环加成反应高效、区域选择性合成新型功能化双吡咯里嗪衍生物的方法。该方法具有高效、温和的反应条件、一锅法和操作方便等优点。对许多化合物进行了体外抗癌细胞增殖活性评价，发现几种化合物具有良好的活性。
